(2004) Oliveira, Cecília Maria Alves de; Silva, Maria do Rosário Rodrigues; Kato, Lucília; Silva, Cleuza Conceição da; Ferreira, Heleno Dias; Souza, Lucia Kioto de
The leaves of Hyptis ovalifolia Benth. (Lamiaceae) were subjected to hydrodistillation and the
resulting volatiles were investigated by GC/MS. The main constituent representing 60% of the
essential oil was isolated by column chromatography and identified by spectroscopic methods as
(R)-6-[(Z)-1-heptenyl]-5,6-dihydro-2H-pyran-2-one (1). This compound showed strong in vitro
activity against four dermatophyte fungi Microsporum canis, Microsporum gypseum, Tricophyton
mentagrophytes, and Tricophyton rubrum (a total of 60 strains) with a minimal inhibitory concentration
observed in the range of 125-7.8 μg mL-1.