β-carboline alkaloids from galianthe ramosa inhibit malate synthase from Paracoccidioides spp.
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2014
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As part of our continuing chemical and biological
analyses of Rubiaceae species from Cerrado, we
isolated novel alkaloids 1 and 2, along with
known compounds epicatechin, ursolic acid, and
oleanolic acid, from Galianthe ramosa. Alkaloid 2
inhibited malate synthase from the pathogenic
fungus Paracoccidioides spp. This enzyme is con-
sidered an important molecular target because it
is not found in humans. Molecular docking simu-
lations were used to describe the interactions be-
tween the alkaloids and malate synthase.
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FREITAS, Carla S. de; KATO, Lucilia; OLIVEIRA, Cecília M. A. de; QUEIROZ JR, Luiz H. K; SANTANA, Mábio J.; SCHUQUEL, Ivânia T.; DELPRETE, Piero G.; SILVA, Roosevelt A. da; QUINTINO, Guilherme O.; SILVA NETO, Benedito R. da; SOARES, Célia M. A.; PEREIRA, Maristela. β-carboline alkaloids from galianthe ramosa inhibit malate synthase from Paracoccidioides spp.. Planta Medica, Stuggart, v. 80, n. 18, p. 1746-1752, 2014.