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dc.creatorFerreira, Raquel Teixeira-
dc.creatorCoutinho, Marcela Araújo Soares-
dc.creatorMalvar, David do Carmo-
dc.creatorCosta, Elson Alves-
dc.creatorFlorentino, Iziara Ferreira-
dc.creatorCosta, Sônia Soares-
dc.creatorVanderlinde, Frederico Argollo-
dc.date.accessioned2018-09-04T12:28:39Z-
dc.date.available2018-09-04T12:28:39Z-
dc.date.issued2014-
dc.identifier.citationFERREIRA, Raquel Teixeira et al. Mechanisms underlying the antinociceptive, antiedematogenic, and anti-inflammatory activity of the main flavonoid from. Evidence-Based Complementary and Alternative Medicine, London, v. 2014, p. 1-8, 2014.pt_BR
dc.identifier.issn1741-427X-
dc.identifier.issne- 1741-4288-
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/15818-
dc.description.abstractKalanchoe pinnata (KP) is popularly used for treating inflammatory diseases. This study investigated the antinociceptive, antiedematogenic, and anti-inflammatory potential of the subcutaneous administration of KP flower aqueous extract (KPFE), its ethyl acetate (EtOAcF) and butanol (BuOHF) fractions, and the main KP flavonoid [quercetin 3-O-α-L-arabinopyranosyl (1 → 2) α-L-rhamnopyranoside] (KPFV) in mice, as well as its possible mechanisms of action. KPFE (30–300 mg/kg) and KPFV (1– 10 mg/kg) inhibited the acetic acid-induced writhing (ID 50 = 164.8 and 9.4 mg/kg, resp.). KPFE (300 mg/kg), EtOAcF (12 mg/kg), BuOHF (15 mg/kg), or KPFV (0.3–3.0 mg/kg) reduced leukocyte migration on carrageenan-induced pleurisy (ID 50 = 2.0 mg/kg for KPFV). KPFE (3–30 mg/kg) and KPFV (0.3–3.0 mg/kg) reduced the croton oil-induced ear edema (ID 50 = 4.3 and 0.76 mg/kg, resp.). KPFE and KPFV reduced the TNF-α concentration in the pleural exudates on carrageenan-induced pleurisy test. Moreover, KPFV inhibited COX-1 (IC 50 = 22.1 μg/mL) and COX-2 (IC 50 > 50 μg/mL). The selectivity index (COX-1 IC 50 /COX-2 IC 50 ) was <0.44. These results indicate that KPFE and KPFV produced antinociceptive, antiedematogenic, and anti-inflammatory activities through COX inhibition and TNF-α reduction, revealing that the main flavonoid in KP flowers and leaves plays an important role in the ethnomedicinal use of the plant.pt_BR
dc.language.isoengpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleMechanisms underlying the antinociceptive, antiedematogenic, and anti-inflammatory activity of the main flavonoid frompt_BR
dc.typeArtigopt_BR
dc.publisher.countryGra-bretanhapt_BR
dc.identifier.doi10.1155/2014/429256-
dc.publisher.departmentInstituto de Ciências Biológicas - ICB (RG)pt_BR
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