Microemulsion based on Pterodon emarginatus oil and its anti‐inflammatory potential
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Data
2015-03
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Resumo
This article reports the development of a pharmaceutical product containing vegetable actives from
a Brazilian medicinal plant. The possibility of forming a microemulsion using Pterodon emarginatus
(“sucupira”) oil was evaluated and the anti-inflammatory potential of this microemulsion was also
examined. A formulation was developed using P. emarginatus oil, a mixture of ethoxylated Castor
Oil (Ultramone ® R-540/propylene glycol 2:1) (surfactant/cosurfactant) and distilled water at a ratio of
10:15:75, respectively. The microemulsion which was selected was then subjected to the preliminary
stability test and analyzed in terms of average diameter of droplets, pH, zeta potential, and polydispersity
index, on the 1 st , 7 th , 15 th , and 30 th days after preparation and stored at different temperatures (5 ± 2 °C,
25 ± 2 °C, and 40 ± 2 °C). The anti-inflammatory in vivo activity of both oil and formulation were
evaluated, using the experimental model of croton oil-induced ear edema. The preliminary stability test
showed that the microemulsion stored at 5 and 25 °C retained its original features throughout the 30-
day period. The anti-inflammatory potential of both oil and formulation was shown to be statistically
significant (p < 0.001), when compared to the control group, however, the microemulsion proved to be
more effective (p < 0.05) than the oil when applied directly to the ear.
Descrição
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Pterodon emarginatus/pharmacognosy, Pharmaceutical technology, Pterodon emarginatus/oil/anti-inflammatory activity, Phytomedicine, Microemulsion, Medicinal plants, Pterodon emarginatus/pharmacognosy, Tecnologia farmacêutica, Pterodon emarginatus/óleo/atividade anti- inflamatória, Microemulsão, Fitoterápico, Plantas medicinais
Citação
PASCOA, Henrique et al. Microemulsion based on Pterodon emarginatus oil and its anti-inflammatory potential. Brazilian Journal of Pharmaceutical Sciences, São Paulo, v. 51, n. 1, p. 117-126, Jan./Mar. 2015.