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dc.creatorCouto, Renê-
dc.creatorMartins, Frederico Severino-
dc.creatorConceição, Edemilson Cardoso da-
dc.creatorFreitas, Luis Alexandre Pedro de-
dc.creatorBara, Maria Teresa Freitas-
dc.creatorPaula, José Realino de-
dc.identifier.citationCOUTO, Renê O. et al. Spray drying of Eugenia dysenterica extract: effects of in-process parameters on product quality. Revista Brasileira de Farmacognosia, Curitiba, v. 23, n. 1, p. 115-123, Jan./Feb. 2013.pt_BR
dc.description.abstractA 2 3 full factorial design was used to assess the impact of spraying air fl ow rate (30-50 L/min), drying air inlet temperature (90-150 oC) and extract feed rate (4-6 g/min) on the quality of Eugenia dysenterica DC., Myrtaceae, spray-dried extracts. Response surface methodology (RSM) was applied to analyze the signifi cance of the effects of process factors on product quality and to obtain fi tted equations to predict dry powder properties. Powder yields were satisfactory, ranging from 34.64 to 63.92%. The dried products showed moisture contents and water activities below 5% and 0.5, respectively. The recuperation ratios of total polyphenols, tannins and fl avonoids ranged from 88.66 to 99.07%, 70.38 to 81.87% and 74.51 to 98.68%, respectively. Additionally, in some conditions the parameters related to dry product’s fl owability and compressibility varied over a range acceptable for pharmaceutical purposes. RSM proved that studied factors signifi cantly affected most of the quality indicators at different levels. The spray drying technology is an attractive and promising alternative for the development of intermediate phytopharmaceutical products of E. dysenterica.pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectEugenia dysentericapt_BR
dc.subjectResponse surface methodologypt_BR
dc.subjectSpray dryingpt_BR
dc.titleSpray drying of Eugenia dysenterica extract: effects of in-process parameters on product qualitypt_BR
dc.identifier.doi10.1590/S0102-695X2012005000109 -
dc.publisher.departmentFaculdade de Farmácia - FF (RG)pt_BR
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