Development and physical evaluation of Maytenus ilicifolia effervescent granules using factorial design
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Data
2014-06
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Resumo
The medicinal plant Maytenus ilicifolia is a commonly used phytomedicine for the treatment of gastritis.
The high dose required and low density of these extracts make necessary a daily intake of several capsules,
hindering adherence to the medication. The purpose of this work was to develop a suitable dosage form
for the administration of Maytenus ilicifolia using effervescent granules. A 2 3 factorial design was
used to study the physical characteristics of the granules (particle size distribution, repose angle, Carr
index, scanning electron microscopy and disintegration time). Moisture stability was also determined.
According to the experimental design, granule size is the most important factor in determining the flow
characteristics of effervescent granules. In turn, the disintegration time is controlled by the content
of sodium bicarbonate present in the effervescent mixture as well as the granule size. The stability
of formulations when exposed to moisture is strongly influenced by the percentage of effervescent
mixture present in the vegetal granules. Precautions in handling and storage should be taken to ensure
the stability of these preparations. The effervescent granules produced from Maytenus ilicifolia met the
pharmacopoeial quality parameters, with appropriate mechanical and physical characteristics and proved
to be a promising vehicle for plant extracts.
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Palavras-chave
Maytenus ilicifolia/pharmacognosy, Plant extracts/administration vehicle, Maytenus ilicifolia/Effervescent granules, Effervescent granules/water sorption behavior, Effervescent granules/physical characteristics/factorial design, Maytenus ilicifolia/farmacognosia, Maytenus ilicifolia/granulados efervescentes, Granulados efervescentes/características físicas/planejamento fatorial, Granulados efervescentes/ higroscopicidade, Extratos vegetais/veículo de administração
Citação
CUNHA-FILHO, Marcilio Sérgio Soares da et al. Development and physical evaluation of Maytenus ilicifolia effervescent granules using factorial design. Brazilian Journal of Pharmaceutical Sciences, São Paulo, v. 50, p. 243-250, Apr./June 2014.