Folic acid does not improve semen parametrs in subfertile men: a double-blin, randomized, placebo-controlled study
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Data
2013-06
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Resumo
Objective: It is thought that oral supplementation with
antioxidants might reduce damage caused by reactive
oxygen species in the seminal fluid, and as a consequen-
ce it increases the fertilizing capacity of spermatozoa
due to improvement of sperm parameters.
Methods: The aim of this research is to evaluate the
effect of folic acid supplementation, by semen analy-
sis, in 49 subfertile men with the median age being 35.3
years (±7.7). The experimental group (n= 23) received
5mg of folic acid daily and the control group (n= 26)
received placebo, both groups were treated for three
months. In order to confirm the condition of sub-fertility,
two spermogram were performed with an interval of 15
days between the first and the second test. Moreover,
sexual intercourse and masturbation abstinence were
required for two to five days before collecting the semen
samples (according to the WHO recommendations). Pre
and post-intervention examination was performed in the
same laboratory by two professionals, according to the
WHO criteria, 1999. The chi-square test was applied for
both groups.Results:There was no statistically improvement
in any of the following parameters: concentration, motility,
morphology and vitality of the spermatozoa.
Conclusion: Folic acid treatment alone in doses of 5mg/day
does not improve sperm parameters in sub-infertile men.
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Palavras-chave
Male infertility, Oxidative stress, Antioxidant supplements, Spermogram, Folic acid, Infertilidade masculina, Suplementos antioxidantes, Estresse oxidativo, Ácido fólico, Espermograma
Citação
SILVA, T. M.; MAIA, M. C. S.; ARRUDA, J. T.; APPROBATO, F. C.; MENDONCA, C. R.; Approbato, M.S. Folic acid dos not improve semem parameters in subfertile men: a double-blind randomized, placebo controlled study. Jornal Brasileiro de Reprodução Assistida, Brasília, DF, v. 17, n. 3, p. 152-157, May/June 2013.