Vasorelaxant and hypotensive effects of jaboticaba fruit ( Myrciaria cauliflora</i> ) extract in rats
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2015
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This study’s aim was to determine the effect of hydroalcoholic extract of M. cauliflora (HEMC) on vascular tension and blood
pressure in rats. In our in vitro studies using precontracted isolated aortas from rats, HEMC and acetylcholine (positive control)
induced relaxation only in vessels with endothelium. Pretreatment with L-NAME (NO synthase inhibitor) or ODQ (soluble
guanylyl cyclase (sGC) inhibitor) abolished the HEMC-induced relaxation. The treatment with MDL-12,330A (adenylyl cyclase
(AC) inhibitor) or diclofenac (COX inhibitor) reduced HEMC-induced vasorelaxation. The blockade of muscarinic and 𝛽-
adrenergic receptors (by atropine and propranolol, resp.) did not promote changes in HEMC-induced vasorelaxation. In our in vivo
studies, catheters were inserted into the right femoral vein and artery of anesthetized rats for HEMC infusion and the measurement
of blood pressure, heart rate, and aortic blood flow. The intravenous infusion of HEMC produced hypotension and increased aortic
blood flow with no changes in heart rate. These findings showed that HEMC induces endothelium-dependent vascular relaxation
and hypotension with no alteration in heart rate. The NO/sGC/cGMP pathway seems to be the main cellular route involved in the
vascular responsiveness.
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ANDRADE, Daniela Medeiros Lobo de et al. Vasorelaxant and hypotensive effects of jaboticaba fruit ( Myrciaria cauliflora</i> ) extract in rats. Evidence-Based Complementary and Alternative Medicine, London, v. 2015, p. 1-8, 2015.