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dc.creatorKorim, Willian Seiji-
dc.creatorFerreira-Neto, Marcos Luiz-
dc.creatorPedrino, Gustavo Rodrigues-
dc.creatorPilowsky, Paul M.-
dc.creatorCravo, Sergio Luiz Domingues-
dc.identifier.citationKORIM, Willian Seiji et al. Interaction of medullary P2 and glutamate receptors mediates the vasodilation in the hindlimb of rat. Purinergic Signalling, Dordrecht, v. 8, n. 4, p. 715-728, 2012.pt_BR
dc.description.abstractIn the nucleus tractus solitarii (NTS) of rats, blockade of extracellular ATP breakdown to adenosine reduces arterial blood pressure (AP) increases that follow stimulation of the hypothalamic defense area (HDA). The effects of ATP on NTS P2 receptors, during stimulation of the HDA, are still unclear. The aim of this study was to determine whether activation of P2 receptors in the NTS mediates cardiovascular responses to HDA stimulation. Further investigation was taken to establish if changes in hindlimb vascular conductance (HVC) elicited by electrical stimulation of the HDA, or activation of P2 receptors in the NTS, are relayed in the rostral ventrolateral medulla (RVLM); and if those responses depend on glutamate release by ATP acting on presynaptic terminals. In anesthetized and paralyzed rats, electrical stimulation of the HDA increased AP and HVC. Blockade of P2 or glutamate receptors in the NTS, with bilateral microinjections of suramin (10 mM) or kynurenate (50 mM) reduced only the evoked increase in HVC by 75 % or more. Similar results were obtained with the blockade combining both antagonists. Blockade of P2 and glutamate receptors in the RVLM also reduced the increases in HVC to stimulation of theHDA by up to 75 %. Bilateralmicroinjections of kynurenate in the RVLM abolished changes in AP and HVC to injections of the P2 receptor agonist α,β-methylene ATP (20 mM) into the NTS. The findings suggest that HDA-NTS-RVLM pathways in control of HVC are mediated by activation of P2 and glutamate receptors in the brainstem in alerting-defense reactions.pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectHypothalamic defense areapt_BR
dc.subjectBlood flowpt_BR
dc.titleInteraction of medullary P2 and glutamate receptors mediates the vasodilation in the hindlimb of ratpt_BR
dc.identifier.doie- 1573-9546-
dc.publisher.departmentInstituto de Ciências Biológicas - ICB (RG)pt_BR
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