Central activities of hydroalcoholic extract from Lafoensia pacari A. St.-Hil. stem bark
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Data
2010-09
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Resumo
Lafoensia pacari A. St.-Hil. can be found from Amapá to Rio Grande do Sul states, and also in Paraguay
and Bolivia. It is popularly known as pacari or mangava-brava and is used to promote weight loss, as
an anti-thermal or tonic, to treat gastritis, ulcers, scarring, itching, discouragement, and cancer. In the
open field tests, the hydroalcoholic extract from L. pacari stem bark (HEP) decreased the number of
rearings, number of invaded squares, and increased immobility time compared to control animals. In
the pentobarbital-induced sleep time test, HEP decreased latency time to sleep and increased sleeping
time. In the rota-rod test, no changes in the studied parameters were observed. In the elevated plus maze,
HEP increased the percentage time and percentage entries in the open arms, indicating that this extract
exerts an anxiolytic-like activity.
Descrição
Palavras-chave
Lafoensia pacari A. St.-Hil./pharmacognosy, Lafoensia pacari A. St.-Hil/farmacognosia, Central Nervous System/ experimental study, Anxiety/experimental study, Hydroalcoholic extract, Extrato etanólico, Sistema Nervoso Central/ estudo experimental, Ansiedade/estudo experimental
Citação
GALDINO, Pablinny Moreira et al. Central activities of hydroalcoholic extract from Lafoensia pacari A.St.-Hil.Stem bark. Brazilian Journal of Pharmaceutical Sciences, São Paulo, v. 46, n. 3, p. 455-462, Jully/Sept. 2010.