Efeito renoprotetor das drogas anti-hipertensivas
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Data
1998-12
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Resumo
It is well known the impact of systemic hypertension in the rate of loss of renal function in different clinical situations and
experimental models. In kidney diseases hypertension entrances the renal injury and accelerates the outcome of chronic renal
failure. Reduced renal man causes hemodynamic and functional adaptation in the remnant renal units that causes progressive
glomerular sclerosis and interstitial fibrosis. Some anti-hypertensive drugs such as angiotensin connecting enzyme inhibitors
cause efferent arteriolar vasodilation, reducing the glomerular hypertension and hyperfiltration, and by this effect can
additionally protect the kidney, besides reducing the systemic arterial pressure. This renoprotective action well demonstrated
in diabetic nephropathy is also evident in non-diabetic nephropathy. Besides the converting enzyme inhibitor, some nondihydropiridinic calcium channel blockers have similar effect. Therefore, anti-hypertensive treatment in patients with kidney
disease must be choosing regarding renal function preservation.
Descrição
Palavras-chave
Hypertension, Kidney diseases, Anti-hypertensives, Renoprotection, Hipertensão, Doença renal, Antihipertensivos, Renoproteção
Citação
CAETANO, Edna Regina Silva Pereira; PRAXEDES, José Nery. Efeito renoprotetor das drogas antihipertensivas. Hiperativo, Rio de Janeiro, v. 5, n. 4, p. 234-241, out./dez.