Sepsis-induced acute kidney injury: biomarkers for diagnosis
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Data
2017-09
Título da Revista
ISSN da Revista
Título de Volume
Editor
Ruy de Souza Lino Junior
Resumo
Sepsis is a major global health problem leading to the increased incidence of death in
intensive care units. In recent years, despite technological advances, the number of cases
has grown significantly. Among the main complications presented by septic patients, acute
renal dysfunction is largely responsible for the high mortality rate. Initially, the reduction of
renal function is associated with focal tubular injury with preserved glomerular morphology
and systemic hemodynamic alterations. During sepsis development, the progressive decrease
in urinary volume and reduction of the glomerular filtration rate associated with increased
serum levels of urea and creatinine are considered classic markers of severe kidney injury.
Despite the valuable role of these serum markers regarding renal function, these data provide
an incomplete scenario of the patient, since many renal disorders may occur in individuals
with increased plasma concentrations of urea and creatinine. Taking into account the important
role of systemic inflammatory processes in the development of acute kidney injury induced
by sepsis, the search for new markers presenting high sensitivity and specificity capable of
detecting early renal injury is still necessary. Thus, the present review summarizes important
aspects of pathophysiology of acute kidney dysfunction induced by sepsis and presents an
updated view of possible new biomarkers associated with the development of acute kidney
injury. Understanding these markers allows important advances leading to new therapeutic
approaches, indicating a new horizon in the diagnosis and treatment of acute kidney injury in
sepsis.
Descrição
Palavras-chave
Sepsis, Acute kidney injury, Diagnostic biomarkers
Citação
RODRIGUES, Vanessa Marcelino; FREITAS, Ana Caroline Silva de; FIGUEIREDO, Maria José; MACHADO, Juliana Reis; MENEZES, Liliana Borges de; SOAVE, Danilo Figueiredo; CELES, Mara Rubia Nunes. Revista de Patologia Tropical, Goiânia, v. 46, n. 3, p. 221-232, jul./set. 2018. Disponível em: https://www.revistas.ufg.br/iptsp/article/view/49681/24414.