Mestrado em Assistência e Avaliação em Saúde (FF)

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Navegando Mestrado em Assistência e Avaliação em Saúde (FF) por Por Orientador "Reis, Angela Adamski da Silva"

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    Avaliação molecular dos polimorfismos genéticos na performance motora de atletas de futebol
    (Universidade Federal de Goiás, 2019-06-28) Menezes, Wandelisa Cançado Flores; Santos, Rodrigo da Silva; http://lattes.cnpq.br/4806187026900959; Reis, Angela Adamski da Silva; http://lattes.cnpq.br/3243656364470085; Santos, Angela Adamski da Silva; Feres, Valéria Christina de Rezende; Lira, Cláudio André Barbosa de; Lopes, Flávio Marques; Mourão, Aline Andrade
    Several genes have been identified as critical in athletic performance. The angiotensin- converting enzyme (ACE) insertion/deletion (I/D) polymorphism has been related to improvements in performance and exercise duration. However, there are large divergences among the studies with on the influence of ACE I/D polymorphism results for physical performance. Other studies have demonstrated that strenuous exercise generally overloads the endogenous antioxidant system’s capacity, leading to oxidative damage to muscles and other tissues in athletes. Moreover, few studies reported significant associations between Glutathione S-Transferases (GST) deletion polymorphisms and resistance performance in athletes. This first study on the central Brazilian population aimed to characterize the effects of ACE I/D and GST deletion polymorphisms on young soccer players. We investigated 65 soccer players from the Under-20 (18 to 20 years old) soccer teams and 60 non-athletes in a case-control study. All subjects had their physical performance investigated through the Running-based Anaerobic Sprint Test (RAST). Genotyping was performed using real-time Polymerase Chain Reaction. We found that the I/D genotype was significantly more frequent in athletes compared with the non- athletes (p=0.01). Individuals with the ID and DD genotypes had an approximately 3.13- fold and 4.37-fold increase in strength and power-orientated performance, respectively. The DD genotype in athletes presented results considered as excellent to good when compared with non-athletes for RAST test. For the association of the GST deletion polymorphisms and RAST test, there was no influence in the athletic performance. Most importantly, we described the associations between ACE I/D polymorphism and athletic performance. In this study, we found that GST polymorphisms indicated no associations for the risk of oxidative damage to the muscle. Our findings may help to select young players with the most favorable genetic potential to succeed as soccer athletes.
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    O polimorfismo I/D do gene ECA e nefropatia diabética: evidências baseadas em meta-análises
    (Universidade Federal de Goiás, 2018-06-04) Silveira, Luciana Carvalho; Santos, Rodrigo da Silva; http://lattes.cnpq.br/4806187026900959; Reis, Angela Adamski da Silva; http://lattes.cnpq.br/3243656364470085; Reis, Angela Adamski da Silva; Santos, Rodrigo da Silva; Ternes, Yves Mauro Fernandes; Alcântara, Erikson Custódio
    Diabetic Nephropathy (DN) is a microvascular renal complication of Diabetes Mellitus (DM), characterized by increased albuminuria and progressive loss of renal function. A cumulative incidence of ND in the last 10 years was observed in 40%, mainly in patients with type 2 diabetes mellitus (T2DM), being an important cause of morbidity and mortality among these individuals. The Insertion / Deletion (I/D) polymorphism in the ACE gene could influence the predisposition to DN by vascular modulation in the kidney, through a direct effect on the cellular hypertrophy, influencing the proliferation and the rupture of the extracellular matrix. Many studies about this subject are discordant, a fact that increases the need for joint analysis so that safe conclusions can be generated. The aim of this study was to investigate the association between ACE gene I/D polymorphism and the development of DN in patients with T2DM. Through a standardized research protocol, the bibliographic search was performed in the PubMed and Cochrane Library electronic databases of 1995-2017, selecting case-control observational studies using the terms "polymorphism" AND " ACE gene" AND “diabetic nephropathy ". We included 33 studies in qualitative synthesis and 30 studies for meta- analysis, with 9.077 participants with T2DM genotyped, 4.774 (52, 6%) individuals with DN and 4.303 (47. 4%) individuals without DN. Evaluated separately, the genotypes for the case group, we have I/I (23, 5%), I/D (46, 4%) and D/D (30, 6%). The genotypes for the control group, I/I (28, 6%), I/D (46.19%) and D/D (25%). The highest prevalence observed was of the I/D genotype in both groups. In the allele frequencies calculated by the Hardy-Weinberg Test, the mutant D allele presents with 54% in the case group and 48% in the control group. The wild-type I allele was present in 46% in the case group and 52% in the control group. The present meta-analysis concludes the I/D polymorphism of the ACE gene studied through the I/D and D/D genotypes is not associated with the risk of developing DN in individuals with T2DM, but the presence of the D allele has significant significance in the risk of developing the disease, as well as the protective role of the I allele.