Programa de Pós-graduação em Medicina Tropical e Saúde Pública
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Navegando Programa de Pós-graduação em Medicina Tropical e Saúde Pública por Por Orientador "Caixeta, Leonardo Ferreira"
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Item Prevalência de alterações cognitivas e funcionais em idosos da comunidade quilombola kalunga(Universidade Federal de Goiás, 2012-03-08) Lopes, Danielly Bandeira; Caixeta, Leonardo Ferreira; http://lattes.cnpq.br/9536747113677509; Lino Júnior, Ruy de Souza; Machado, Delfino da Costa; Caixeta, Leonardo FerreiraThis study was to estimate the prevalence of cognitive and functional elderly residents of the isolated community, remaining Quilombo, located in the northeastern state of Goias, called Kalunga. Cross-sectional study with noninvasive methods, based on primary data of cognitive and functional elderly aged above 60 years of quilombo Kalunga, the northeastern state of Goiás were collected and analyzed data to identify (age, sex), socio-demographic factors (education, place), cultural and previous morbidities (hypertension, diabetes) participants through semi-structured questionnaire. Data on cognitive and functional assessment were obtained by applying the Mini-Mental State Examination (MMSE) and the Questionnaire of Daily Living (QAVD), respectively. A total of 65 elderly patients were evaluated. . Most were male (52.3%), married (58.5%), illiterate (93.8%) and mean age of 71.58 years, ranging between 60 and 93 years. The prevalence of individuals with cognitive and functional change was 9.2% (n = 6), and the functional change (18.5%) was more prevalent than cognitive (12.3%). The prevalence rate of cognitive and functional changes detected in this study was low compared to other studies conducted in Brazil, but were similar to studies in other populations.Item Incidência de demência em idosos negros de comunidade quilombola (Kalunga) ancestral isolada(Universidade Federal de Goiás, 2015-12-16) Lopes, Danielly Bandeira; Caixeta, Leonardo Ferreira; http://lattes.cnpq.br/9536747113677509; Vieira, Renata Teles; Azevêdo, Paulo Verlaine Borges e; Costa, Érico de Castro e; Dorta, Mirian Cristina Leandro; Caixeta, Leonardo FerreiraPopulation aging is a global phenomenon that will continue to reach all regions of the world. The main changes that can be followed by the aging are with respect to cognitive and functional aspects. This study aimed to estimate the incidence of cognitive and functional changes in the elderly living in isolated community, reminiscent of quilombo, located in the northeastern of Goias state, called Kalunga. We conducted a longitudinal study with noninvasive methods, based on primary data of cognitive and functional changes of the elderly who participated in prevalence study in 2011. Were collected and analyzed identification data (age, gender), socio-demographic factors (education, place), cultural and prior morbidities (hypertension, diabetes) participants through semi-structured questionnaire. The cognitive and functional data were obtained by applying the Mini Mental State Examination (MMSE) and the Pfeffer Functional Activities Questionnaire (PFAQ), respectively. In total were reassessed 43 elderly. Most were male (51.2%), married (69.8%), illiterate (90.7%) with a mean age of 74.2 years, hypertension (53.5%) and smoker (48.8%). The incidence of individuals with cognitive and functional change was 4% year, similar in comparison to other studies on cognitive disorders and dementia. Only low levels of schooling and the presence of diabetes mellitus presented a significant association with the individuals' cognitive and functional profile. However, there was a significant decline in cognition and functionality of these assessed in 2011 and reassessed in 2014.Item Características clínicas e laboratoriais de uma doença neurológica rara e hereditária em uma família do Brasil central(Universidade Federal de Goiás, 2016-06-09) Medeiros, Rodrigo Parente; Caixeta, Leonardo Ferreira; http://lattes.cnpq.br/9536747113677509; Caixeta, Leonardo Ferreira; Teixeira, Kim Ir Sen Santos; Mendonça, Helena Rezende SilvaA rare disease is defined by the World Health Organization as diseases that affect up to 65 people / 100,000. To evaluate these diseases it is required to be performed a lot of tests and it is often not possible to reach a definitive diagnosis. The aim is to describe the clinical and neuroimaging aspects in a countryside Goiás’ family that carries a rare neurodegenerative disease. It’s a descriptive study about five brothers. It’s conducted physical examinations, laboratory, MRI of the cervical column, dorsal and lumbar besides the skull. Made neurophysiological diagnosis, Through genetic sequencing to make exome. We were subjected to neuropsychological assessment, the MEEM and FIM. The five brothers have in common the tetraparesia of crural predominance , muscular atrophy of the lower limbs , severe mental retardation early onset , cerebellar atrophy , paravertebral atrophy and motor axonal neuropathy. Made sequencing the exome for research related genes hereditary spastic paraparesis and not found any gene related to this disease. A probable diagnosis would be the spinocerebellar ataxia type 13, due to the reported clinical picture. But it is necessary a genetic study to proof it. Continuous genetic evaluation of these patients is important because of the description of new genes.Item Avaliação neuropsicológica no diagnóstico diferencial das demências infecto parasitárias e degenerativas(Universidade Federal de Goiás, 2010-06-08) Soares, Vânia Lúcia Dias; Caixeta, Leonardo Ferreira; http://lattes.cnpq.br/9536747113677509Neuropsychological assessment and differential diagnosis between infective and degenerative dementias.. There are no studies comparing the neuropsychological profile of patients with parasitic infectious dementia (DIP) and other forms of primarily degenerative dementia. The objectives were to compare the neuropsychological deficits present in three groups of patients with dementia and a normal control group in relation to the DIP group. For this purpose, we prospectively evaluated 130 individuals with dementia from Dementia Unit, Hospital das Clinicas, Federal University of Goias and from the Tropical Diseases Hospital, Goiânia, aged above 18 years, divided in the following groups: infectious dementia (DIP), Alzheimer's disease (AD) , frontotemporal lobar degeneration(DLFT) , parkinsonism plus (PP) and normal controls. All underwent extensive neuropsychological assessment, addressing all cognitive domains (verbal and visual memory, attention, executive functions, gnosis, praxis, visuospatial skills, language). The productions were transcribed into tables and quantified by specific tests (Stroop, Trail Making A / B, Cancelation Test, Maze, Digit Span, Rey Figure, RAVLT, Logical Memory, Verbal Fluency, Hooper and Proverbs from WAIS). The DIP group generally presented with severe neuropsychological deficits present in multiple cognitive domains, and possibly even higher than those presented by primarily degenerative dementia in the elderly. These cognitive deficits can signal that the functional and / or lesional disturbances in DIP group undertake extensive brain areas or even that are impaired basic neuropsychological functions (attention, executive functions) that support the other functions with which are interdependent (memory, visuospatial functions). The DIP group had a higher run time, and committed more errors in the bell cancellation test than the control group (p <0.001), indicating deficits in selectivity and planning suggestive of involvement of fronto-subcortical areas. Overall, the DIP group had a performance in memory tasks higher than the AD group, equal to the DLFT group and lower than the PP group, suggesting the presence of heterogeneous hippocampal pathology in DIP group. The results emphasize that the neuropsychological assessments aid in the differential diagnosis of dementia and the topographic location of lesions associated with the predominant profile of cognitive dysfunction.