Programa de Pós-graduação em Biologia da Relação Parasito-Hospedeiro
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Navegando Programa de Pós-graduação em Biologia da Relação Parasito-Hospedeiro por Autor "Araújo, Paula Sampaio"
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Item Atividade moluscicida de nanopartículas de prata funcionalizadas com polivinilpirrolidona nos estágios iniciais de desenvolvimento do caramujo Biomphalaria glabrata (Say, 1818)(Universidade Federal de Goiás, 2020-03-16) Araújo, Paula Sampaio; Rocha, Thiago Lopes; http://lattes.cnpq.br/6325937100056775; Rocha, Thiago Lopes; Monteiro, Caio Marcio de Oliveira; Barreto, Lucas PradoSchistosomiasis is a tropical disease of an endemic nature caused by the parasite Schistosoma mansoni and its intermediary host is freshwater snails, such as Biomphalaria glabrata. Among the disease control methods, the intermediate host control stands out through the use of molluscicides. Nanotechnology appears as a viable alternative for the development of new molluscicides. Among the nanoparticles with potential molluscicidal use, silver nanoparticles (Ag NPs) stand out due to their inherent physical and chemical properties, with an effect against bacteria, fungi, viruses and protozoa. Thus, the general objective of the present study was to evaluate the molluscicidal potential of PVP-functionalized Ag NPs for different stages of development (embryos, newly hatched) of the snail B. glabrata. The bioassays were carried out during the embryonic development phase and in newly hatched snails for a total period of 144 h and 96 h, respectively, using concentrations from 12.1 to 1560 g L-1. Biomarkers such as mortality rate, hatch rate and morphological alteration were analyzed, together with the estimated average lethal concentration. Results showed that the embryos were more resistant to Ag NPs than the newly hatched. The toxicity was demonstrated during all phases analyzed in a concentration-dependent manner. Exposure to Ag NPs induced the formation of hydropic embryos. This was the first study that evaluated the toxicity of Ag NPs and their dissolved counterpart (AgNO3) in embryos and newly hatched snails B. glabrata.