Avaliação da toxicidade oral aguda e atividade diurética de Celtis iguanaea (Jacq.) Sargent
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Data
2011-08-30
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Universidade Federal de Goiás
Resumo
Celtis iguanaea (Jacq.) Sargent is a species commonly known as cock-spur, in the
Ulmaceae family and characterized as a shrub or small tree with branches long and
very flexible. Is used for the treatment of urinary tract infections, kidney (kidney
stones and pyelonephritis) and as a diuretic. Popular reports in the State of Goiás
indicate the use of the spur cockscomb in the form of tea leaves. The aqueous
extract of Celtis iguananea was tested in Wistar rats to assess single dose diuretic
activity in observing the effect of same on urinary volume and products of metabolism
(urea and creatinine) and assess the multiple-dose diuretic activity by observing the
effect on the urinary volume and urinary excretion of electrolytes sodium (Na +) and
potassium (K +), and also in Wistar rats and mice Swiss to test its acute oral toxicity
following the Guide 423 (OECD), in which the animals were observed for 14 days
after single administration of 2000mg/kg of extract, including this test the
histopathological study of heart, lung, kidneys, liver, spleen, pancreas and intestines.
The aqueous extract of cock-spur in their three doses (70, 200 and 600 mg/kg) did
not submit multiple dose diuretic activity and only because it has not increased the
excretion of water, electrolytes and metabolites of neither. The extract was framed in
the class 5 (substance with Ld50 more than 2000 mg/kg and less than 5000 mg/kg),
being considered of low toxicity, but histopathological findings cardiotoxicity and
nephrotoxicity suggested does not extract any acute oral toxicity test (2000mg/kg),
with an increase of absolut weight from the kidney and heart of male rats and mices
treated with the extract and microscopic examination of kidney of male rats showing
marked presence of cylinder hialinos no glomerulus.
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GONÇALVES, Nádyla Zanon. Evaluation of acute oral toxicity and diuretic activity of Celtis iguanaea (Jacq.) Sargent. 2011. 68 f. Dissertação (Mestrado em Ciências da Saúde - Farmácia) - Universidade Federal de Goiás, Goiânia, 2011.