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Item Vaginose bacteriana e tricomoníase: prevalência, fatores associados e desempenho de testes diagnósticos em mulheres atendidas em ambulatório de ginecologia preventiva(Universidade Federal de Goiás, 2022-02-21) Camargo, Kélvia Cristina de; Saddi, Vera Aparecida; http://lattes.cnpq.br/7496804650895441; Alves, Rosane Ribeiro Figueiredo; http://lattes.cnpq.br/8335736301768972; Alves, Rosane Ribeiro Figueiredo; Santos, Silvia Helena Rabelo dos; Matos, Marcos André de; Barbosa, Maria Alves; Ribeiro, Andrea AlvesINTRODUCTION. Bacterial vaginosis BV and genital infections have a great impact on women's health and are the main causes of demand for health services. GOALS. To investigate the prevalence, associated factors and performance of diagnostic methods for BV and Trichomonas vaginalis TV. METHODS. The thesis is presented in articles, in an original cross-sectional article and a systematic review. The Crosssectional study, conducted with women seen at a preventive gynecology clinic, in the public network of Goiânia, referred to a gynecological consultation. Gynecological examination with evaluation of the characteristics of the vaginal secretion, and the collection of cervicovaginal material for cytological study, fresh examination, vaginal pH, Whiff test, Gram-stained bacterioscopy and the polymerase chain reaction (PCR) for the detection of TV . The samples were analyzed at the Genetic Diversity Laboratory of the Pontifical Catholic University of Goiás (PUC GO) and at the Rômulo Rocha Clinical Analysis Center of the Faculty of Pharmacy of the Federal University of Goiás (FF/UFG). Sociodemographic and behavioral characteristics were analyzed using descriptive statistics. Logistic regression analysis was performed to identify factors associated with BV. The degree of agreement between the clinical characteristics of the vaginal secretion and the different diagnostic methods was evaluated by the Kappa index. The systematic review study was registered in the International Prospective Register of Systematic Reviews (PROSPERO) and performed according to the methodological guidelines of the “Preferred Reporting Items for Systematic Reviews and Meta-Analyses” (PRISMA). The search was performed on PubMed and Scopus databases in September 2021, with no language restriction. Articles were considered eligible if they investigated the prevalence of BV in Brazil; used Amsel's clinical diagnostic criteria or Gram-stained bacterioscopy in women of reproductive age and without comorbidities. Studies were evaluated by two investigators to establish reliability. The risk of bias and the quality of the selected studies were assessed using the Joana Briggs Institute (JBI) tool. RESULTS. The cross-sectional study showed a prevalence of BV, according to the Nugent criteria, of 33.7% and of trichomoniasis by PCR, of 0.5%. The complaint of abnormal vaginal secretion was significantly associated with the diagnosis of BV (OR = 2.2; 95%CI: 1.0- 4.5); The diagnostic accuracy for BV, by the methods of Amsel, Ison & Hay and cytological examination, compared to the Nugent criteria was 35.6%, 97.0% and 84.2%, respectively. The sensitivity and degree of agreement for the diagnosis of TV, by the fresh test was 0.0% and 0.0% and by the cytological test, 100% and 1, respectively. Systematic review included ten articles. The mean prevalence of BV in the included studies was 25.4% (95%CI: 24.0-26.8), ranging from 15.3% (95%CI: 11.8- 19.4) to 51. 0% (95%CI: 43.1-58.7). In three population-based studies, the prevalence ranged from 15.3% (95%CI:11.8-19.4) to 20% (95%CI:16.9-23.6), with a mean of 18,1% (CI:16.0-20.5). In seven clinical-based studies, the prevalence ranged from 18.6% (95%CI: 13.6-25.0) to 51% (95%CI: 43.1-58.7), with an average of 27.2% (95%CI: 24.6-29.9). Factors associated with BV were use of sexual accessories (OR: 2.4; 95%CI: 1.1-4.9), single marital status (OR: 1.4; 95%CI: 1.1-1.8), partner infidelity (OR: 1.5; 95%CI: 1.2-1.9), abnormal vaginal discharge (OR: 1.5; 95%CI:1.2-2.0), presence of trichomoniasis (OR: : 4.1 (95% CI: 1.5-11.5).CONCLUSION. The crosssectional study showed a high prevalence of BV and a low prevalence of TV; The report of abnormal vaginal secretion as the only factor associated with BV; the methods with the best diagnostic performance for BV, compared to the Nugent method, were those Abstract xix of Ison and Hay and cytological examination and cytological examination considered to be easily accessible in the daily clinic. The systematic carried out in this study showed a high prevalence of BV and associated factors linked to sexual behavior, although it is not considered a sexually transmitted infection.Item Fatores de risco relacionados ao estresse materno e indicadores neurocomportamentais de recém-nascidos pré-termo em unidade de terapia intensiva neonatal(Universidade Federal de Goiás, 2023-04-01) Ramos, Bruna Abreu; Formiga, Cibelle Kayenne Martins Roberto; http://lattes.cnpq.br/5231575956660644; Amaral, Waldemar Naves do; http://lattes.cnpq.br/4092560599116579; Amaral, Waldemar Naves do; Oliveira, Nayara Rodrigues Gomes de; Sousa, Juarez Antonio de; Ferreira, Rui Gilberto; Vieira, Martina Estevam BromIntroduction: Prematurity is the main cause of hospitalization in the Neonatal Intensive Care Unit, being considered an important factor for adverse infant outcomes, in terms of quality of life. Objectives: To analyze maternal stress and its correlation with neonatal neurobehavioral indicators and to identify the main risk factors (maternal and neonatal) associated with preterm newborns in neonatal intensive care units. Methods: The total study sample consisted of 251 preterm, low birth weight newborns and their respective mothers, who were admitted to the Neonatal Intensive Care Unit and the Neonatal Intermediate Care Unit of a Public Maternity Hospital in the city of Goiania ( GO). An analysis of medical records was performed, the parental stress assessment scale (PSS: NICU) was applied, and finally, the neurobehavioral assessment instrument for preterm newborns (NAPI) was used. For the statistical analysis of the total sample, the Spearman correlation test was performed (p < 0.05) and for the logistic regression analysis, the sample n of 165 participants was used based on the exclusion criteria, in order to test the possible factors of risk for maternal stress. In all analyses, p < 0.05 was considered. Results: Considering the outcome on maternal stress, the level of stress was assessed as moderate among mothers. The subscale that presented the highest level of stress was "Change in the Role of Mother" and the one with the lowest level of stress was "Sounds and Images", with total scores ranging from "little stressful" to "very stressful". . The higher the stress level on the item “the other sick babies in the room” the lower the leg resistance performance (p <0.049). It was also observed that neonatal and maternal risk factors did not present an outcome with maternal stress. The respiratory rate variable of 49.8 bpm and the scarf signal of 60.11 at the time of the neonatal neurobehavioral assessment, was shown to be a protective factor for maternal stress (p <0.05) and adjusted OR <1. Conclusion: The mothers considered the experience of having a newborn hospitalized in the Neonatal Intensive Care Unit moderately stressful. Weak correlations were identified between maternal stress and neonatal neurobehavioral indicators. No relationship was found between neonatal and maternal risk factors for maternal stress, but muscle tone (scarf sign) and respiratory rate at the time of assessment behaved as protective factors for maternal stress.Item Aspectos emocionais e concepções de maternidade de mulheres inférteis em programa de reprodução assistida(Universidade Federal de Goiás, 2022-03-05) Marciano, Rafaela Paula; Amaral, Waldemar Naves do; http://lattes.cnpq.br/4092560599116579; Amaral, Waldemar Naves do; Burgarelli, Cristóvão Giovani; Alves, Rosane Ribeiro Figueiredo; Lima, Priscilla Melo Ribeiro de; Ferreira, Rui GilbertoIntroduction: According to the WHO, infertility affects around 48 million couples worldwide. The reproductive technology provide a privileged field in possible harmonization between the feminine and the desire of having a child. Consider social and psychological importance of motherhood and reproduction in our society, infertility can affect the emotional, sexual and marital relationship spheres. Objectives: To understand the conceptions of motherhood and to analyze the emotional aspects of infertile women of different socioeconomic levels who are undergoing assisted reproduction treatment. Methodology: Descriptive, quali-quantitative study carried out between January and December 2019, in a private clinic and in a public clinic for assisted reproduction, both located in the city of Goiânia, Goiás. The study included 48 women, over 35 years old, undergoing treatment for high-complexity assisted reproduction, half of the sample from each institution. Individual interviews were conducted, which were recorded and transcribed in full. Results: The average age of the participants was 38.9 years, 43.75% of the sample was nulliparous, 56.2% had a female cause of sterility. The variables which had significant statistic difference were the schooling (p=0,005) and family income (p=<0,001). The women from the private clinic have shown higher schooling anda familiar income than from the public one. The participants represented the family in positive way, as a support system, of foundation and origin of love, embracing the family as a social bond. On the other hand the family concepts based on inbreeding were also present representing the family by perpetuation of the specie and by the importance of biological bond. Infertile women reported feelings of inferiority, worthlessness, impotence, inadequacy towards society, which reinforces the stigma of infertility. The prevalent feelings and symptoms were anxiety, anguish, insomnia, binge eating, sadness, frustration, fear and anger. Infertility was represented with negative feelings related to pain, surprise and bitterness, in addition to anger, revolt and indignation, experiencing this situation as injustice against them or as a divine punishment. Conclusions: The results found contribute to necessary reflections on the role of women and our culture, since motherhood is still used as a measure for female success or failure. The woman experiences a dilemma between her desires, her reality and the possibility of choosing motherhood, but the latter is veiledly imperative. In addition, it is possible to raise the discussion on the issue of desire and demand for a biological child, aspects often forgotten in assisted reproduction clinics. At the same time, the possibility of procreation through RT is recognized as something positive for women who have the legitimate desire for biological motherhood and who find in science a possible ally to overcome the mark that their own body imposes on them.Item Relações anatomotopográficas entre raízes e lesões periapicais de dentes superiores posteriores com o seio maxilar(Universidade Federal de Goiás, 2014-10-02) Nunes, Carla Aparecida Bernardes da Costa Meneses; Guedes, Orlando Aguirre; http://lattes.cnpq.br/3219560690903434; Estrela, Carlos; http://lattes.cnpq.br/3611967334176683; Estrela, Carlos; Guedes, Orlando Aguirre; Pécora, Jesus Djalma; Silva, Brunno Santos de Freitas; Alencar, Ana Helena Gonçalves dePurpose: To analyze the topographical anatomic relationship between the maxillary posterior teeth and the maxillary sinus (MS) using cone beam computed tomography (CBCT). Methods: A sample of 202 CBCT examinations, consisting of 600 premolars and 600 molars were selected for the study images. The distance between the root apex and the floor of the MS as well as the thickness of the cortical bone of the floor of the MS in closer to root apex and furcation region was measured. The vertical and horizontal relationships of the MS floor with the roots of the molars were classified according to Kwak et al. (2004) with adaptation. The mean and standard deviation of distances and thicknesses were obtained. The difference between the distances, as well as between cortical thicknesses was evaluated by Kruskal-Wallis test. The difference between the types of the vertical relationship, as well as between the types of the horizontal relationship, of the molars was assessed by Chi-square test. Significant values were considered p < 0.05. Results: The shortest distance between the apex and the MS floor was observed in MB root of the second molar (0.36 ± 1.17 mm) and the longest distance in V root of the first premolar (5.47 ± 4.43 mm). In the group of single-rooted premolar, the closest distance between the apex and the MS floor was observed in the roots of the second premolar (1.71 ± 2.81 mm). The greater cortical thickness of the floor of the MS was observed in the first premolar area (1.28 ± 0. 42 mm) and the lower, in the second molar área (0.65± 0.41 mm). There was no statistically significant difference in the thickness of cortical bone in relation to proximity to the apex of the MB, DB and P roots of the molars. The vertical relationship most observed in the molars was Type 2 and the horizontal was type 2H. Conclusions: The roots of the upper molars showed greater proximity to SM when compared to premolar; the thickness of the cortical bone of the floor of the SM in the region closest to the apex and furcation area was found to be similar; the roots of the upper molars presented more frequently a vertical and horizontal relationship of proximity with the SM.Item O acesso a medicamentos pela via administrativa no setor público de saúde no Brasil(Universidade Federal de Goiás, 2015-05-08) Soares, Amanda Queiroz; Provin, Mércia Pandolfo; http://lattes.cnpq.br/1809891256443044; Amaral, Rita Goreti; http://lattes.cnpq.br/3665611660713029; Amaral, Rita Goreti; Dâmaso, Andréa Homsi; Andrade, Eli Iola Gurgel; Medeiros, Marcelo; Contezini, Silvana Nair LeiteAlthough the Brazilian public healthcare system is based on the principles of the universality and integrality of access to health services, severe problems remain with respect to guaranteeing access to pharmaceutical drugs. This situation has contributed to the creation of new institutional frameworks, including the administrative channel, institutionalized by the executive power with the aim of meeting the repressed demand for pharmaceutical drugs not obtained within the public health service. This study analyzed access to pharmaceutical drugs through the administrative channel within the Brazilian public health sector. As part of this larger study, various methodologies were applied, including a case-control study, a descriptive study and an interpretive case study in which the focal group technique was used. The study was developed in the town of Goiânia, in Brazil’s mid-western region. General users of primary healthcare units (or their accompanying persons), users specifically requesting pharmaceutical drugs through the administrative channel and users who had successfully obtained pharmaceutical drugs through this channel participated in the study. Results show that administrative demands for access to pharmaceutical drugs are inserted within a multifactorial context that involves users’ economic and sociodemographic characteristics, as well as the characteristics of healthcare, pharmaceutical care and healthcare conditions. Furthermore, users who had gained access to at least one pharmaceutical drug requested through the administrative channel were found to be predominantly those who were less socioeconomically vulnerable, those with a positive self-evaluation of their state of health, those requesting insulin analogs and individuals who in general did not consult or obtain medication within the public healthcare sector. The steps taken by most of the individuals who had their request approved reveal their fluidity between the public and private healthcare sectors, characterizing their efforts to guarantee healthcare. Therefore, the administrative channel was found not to be free from the barriers to achieving access to pharmaceutical drugs that exist within the public health sector in view of its interdependency on a system with shortcomings both within the health sector itself and at higher levels within the system.Item A judicialização do fornecimento de medicamentos no Sistema Único de Saúde(Universidade Federal de Goiás, 2023-02-03) Rocha, Danilo Di Paiva Malheiros; Mrué, Fátima; http://lattes.cnpq.br/2424858504979076; Garcíazapata, Marco Túlio Antônio; http://lattes.cnpq.br/3672512339058369; Garcíazapata, Marco Túlio Antônio; Itria, Alexander; Soares, Carolina Chaves; Leão, Ana Lúcia de Melo; Souza Júnior, Edson Sidião deOBJECTIVE: To investigate the phenomenon of Judicialization of Health. METHODOLOGY: Mixed research involving a systematic literature review study and a quantitative and qualitative research. As for the systematic literature review, studies published between 2010 and 2021 were consulted. The quantitative research adopted a time frame between 2017 and 2019, contemplating a sample of 359 health lawsuits against the Municipality of Goiânia. The qualitative study adopted a bibliographical narrative review, with the following steps: selection of the topic and question of interest, definition of descriptors, definition of search sources, selection of relevant articles by reading the title and abstract, reading in full, extraction of the most important information from these articles and synthesis of the main findings. RESULTS: Most studies analyzed the legalization of drugs related to the official list of free distribution. A study from Colombia prioritized the increase in lawsuits. From Argentina, he found that the judges were not concerned about promoting equity. In Costa Rica, drugs were ranked according to their priorities. Of the lawsuits studied, more than half (53%) had a claim value between R$1,000.00 and R$50,000.00, aged between 18 and 59 years (49%), filed by the Goiás Public Defender's Office (78%) . Injunctions were granted in 92% and Nat-Jus heard in 22% of cases and final favorable judgment in 77%. Proposals point to the need for deep knowledge of Clinical Protocols and Therapeutic Guidelines (PCDTs); adoption of organization and management of drug stocks; implementation of support centers for the Judiciary (NATJUS) and; creation of specialized rods. Implemented experiences: “SUS C.O.M VC” in Jundiaí-SP; Technical Support Center added to the Municipal Ombudsman in Araguarina-TO; Drug Conciliation Nucleus in Lages-SC; Regionalized Management Program for the Judicialization of Health in Santa Catarina; REMUME update in Canguçu-RS. CONCLUSION: It is necessary to engage all the professionals involved, demanding institutional dialogue and adopting a multicentric solution for the maintenance of the Public Health System. Proposals and practices for health rationalization are essential measures and deserve to migrate from specific experiences to a national scope.Item Níveis séricos e efeito da suplementação de vitamina D sobre a composição corporal e perfil metabólico de crianças(Universidade Federal de Goiás, 2020-12-21) Alves, Ana Gabriella Pereira; Silva, Maria Sebastiana; http://lattes.cnpq.br/1329422634395496; Silva, Maria Sebastiana; Hadler, Maria Claret Costa Monteiro; Guillo, Lídia Andreu; Santos, Renata Carvalho dos; Martins, Karine AnuscaIntroduction: Vitamin D plays a role in several metabolic pathways, including cell diferentiation and proliferation, hormonal control, modulation of inflammation and immune system regulation. Since vitamin D receptors are presented in different tissues and organs, it is related to many diseases, such as obesity, hipertension and dyslipidemia. Objective: To evaluate the serum levels and the effect of cholecalciferol supplementation on body composition and metabolic profile in of children. Methods: A randomized, placebo-controlled, triple-blind, crossover study was conducted with 62 children, 4 to 11 years old, from a public educational institution, that met the selection criteria. Sociodemographic, economic and sunscreen use data were collected from a specific questionnaire; the body area daily exposed to the sun was evaluated by a questionnaire with a representative figure of the body percentage; a specific questionnaire was used to evaluate physical activity and sedentary behavior; anthropometry (body mass and height) and body composition (waist circumference, body fat percentage, fat-free mass, triceps and subscapular skinfolds) were obtained using a stadiometer, electronic scale, anthropometric tape, tetrapolar bioimpedance and adipometer; blood pressure was measured using an automatic digital monitor; 25-hydroxyvitamin D [25(OH)D], fasting glucose and lipid profile were analysed from blood collection; and food intake data was evaluated through the 24-hour recall. In the intervention study, the two groups, supplemented and placebo, received 5 drops of cholecalciferol (1000 IU/day) and 5 drops of sunflower oil (placebo), respectively, for 12 weeks, separated by 10-week washout period. Results: Among children with sufficient serum vitamin D (≥ 75 nmol/L), who participated in the baseline study, no difference was found in sex, self-reported race, physical activity, age, anthropometry, body composition, biochemical parameters and blood pressure between children with 25(OH)D 75-99 and ≥ 100 nmol/L, in addition to the non-association of 25(OH)D with body composition and metabolic profile. In the crossover study, conducted with hypertriglyceridemic children, cholecalciferol supplementation reduced serum total cholesterol (TC) (p < 0.001), LDL-c (p < 0.001), non HDL-c (p < 0.001), TC/HDL-c (p = 0.001) and LDL-c/HDL-c (p < 0.001) ratio, when compared to placebo group. Conclusions: Serum vitamin D was not associated with body composition and metabolic profile among children with 25(OH) ≥ 75 nmol/L, and 1000 IU/day of cholecalciferol supplementation, for 90 days, in hypertriglyceridemic children without 25(OH)D serum deficiency, was able to improve lipid profile.Item Vínculo parental, saúde mental e catastrofização em mulheres com dor pélvica crônica(Universidade Federal de Goiás, 2022-10-26) Campos, Vânia Meira e Siqueira; Deus, José Miguel de; http://lattes.cnpq.br/8644071247922633; Conde, Délio Marques; http://lattes.cnpq.br/8628571386803692; Conde, Délio Marques; Alcântara, Keila Correia de; Ribeiro, Marília Oliveira; Finotti, Marta Curado Carvalho Franco; Silva, Nílzio Antonio daIntroduction: The experience of pain and its coping strategies, mental disorders such as anxiety and depression, and maladaptive personality traits such as catastrophizing have been associated with parenting styles in childhood. In turn, catastrophizing has been considered an important predictor of outcomes for different types of pain, including chronic pelvic pain (CPP) in women, which is a common and difficult-to-treat health condition. Aims: To perform a narrative review of the available literature on CPP in women. To evaluate the association between parenting style and CPP in women, and to investigate the association between catastrophizing, pain intensity, anxiety, depression, and parenting style in women with CPP. Methods: A search was conducted of the Medline, Embase and SciELO (Scientific Electronic Library Online) databases up to the cut-off date of October 15, 2021. The following terms were used: chronic pelvic pain, central sensitization, hyperalgesia, chronic pain, neuromodulation, women, somatic pain, visceral pain, nociplastic pain and neuropathic pain. An observational case-control study was also conducted between May 2018 and August 2021 with 123 women with CPP and 123 pain-free controls. Sociodemographic, clinical, and behavioral data were investigated. Parental Bonding Instrument was used to assess parenting styles. Generalized Anxiety Disorder-7 e 9-item Patient Health Questionnaire were used to evaluate anxiety and depression, respectively. Pain intensity and catastrophizing were investigated in the CPP group using, respectively, a 10-cm numerical pain rating scale and the Pain Catastrophizing Scale. Yates’s chi-square test and the Mann-Whitney test were used to compare characteristics between the groups. Multiple logistic regression analyses were conducted to determine possible associations between each parenting style and CPP in women, and the odds ratios (OR) and their respective 95% confidence intervals (95%CI) were calculated. Spearman’s correlation coefficient (r) was used to verify possible correlations between catastrophizing, pain intensity, the duration of pain, anxiety, depression, and parental bonding style (maternal and paternal care and overprotection) in the group of women with CPP. Results: A higher frequency of low maternal care (60.7% versus 45.2%; p=0.026), anxiety (79.7% versus 56.9%; p<0.001), depression (73.2% versus 56.1%; p=0.008), physical violence (31.7% versus 14.6%; p=0.003), relationship difficulties (39.8% versus 19.5%; p=0.001), and abdominal/pelvic surgery (78.0% versus 63.4%; p=0.017) were found in the CPP group compared to the control group. The domains of parental bonding were not independently associated with CPP in women. Catastrophizing was identified in 77.2% of women in the CPP group. Catastrophizing women were found to use significantly more pain medication compared to non-catastrophizing women (94.7% vs 78.6%; p=0.024). A positive correlation was found between catastrophizing and pain intensity (r=0.342; p<0.001), anxiety (r=0.271; p=0.002), depression (r=0.272; p=0.002), and maternal overprotection (r=0.185; p=0.046). A negative correlation was found between anxiety and maternal (r=-0.184; p=0.047) and paternal (r=-0.286; p=0.006) care and between depression and maternal (r=-0.219; p=0.018) and paternal (r=-0.234; p=0.026) care in the CPP group. Conclusions: CPP is an challenger condition that may not be associated with an obvious cause. A timely scheme of investigation and treatment of associated comorbidities is recommended. The clinical identification of a central sensitization phenotype can guide the management of women with CPP, which must be interdisciplinary and involve biopsychosocial aspects. Low maternal care was more common in women with CPP compared to the pain-free controls, with no independent association between parental bonding and CPP. Catastrophizing was very common and positively, but weakly, correlated with the intensity of pain, anxiety, depression, and maternal overprotection in the CPP group. Maternal and paternal care was negatively and weakly correlated with anxiety and depression in women with CPP. Our findings suggest further studies on the role of families, particularly fathers and mothers, in the emotional development and pain coping strategies of women with CPP. They also indicate the need for a personalized approach to women with CPP, seeking better therapeutic outcomes.Item Vaginose bacteriana, infecção cervical pelo Papilomavírus humano (HPV) e anormalidades citológicas cervicais em mulheres adultas(Universidade Federal de Goiás, 2022-02-18) Martins, Bruno César Teodoro; Saddi, Vera Aparecida; http://lattes.cnpq.br/7496804650895441; Saddi, Vera Aparecida; Santos, Sílvia Helena Rabelo dos; Alves, Rosane Ribeiro Figueiredo; Barbosa, Maria Alves; Matos, Marcos André deResumo em língua estrangeira: Bacterial vaginosis (BV) is the most common cause of vaginal discharge and occurs when there is an imbalance in the vaginal microbiota, predominantly composed of Lactobacillus spp. Human Papillomavirus (HPV) is the most common sexually transmitted virus in the world. Persistent infection with high-risk HPV genotypes is the main cause of the development of cervical intraepithelial neoplasia and cervical cancer. The aim of this study was to investigate the association between BV, cervical HPV infection and cervical cytological abnormalities in adult women. A systematic review with meta-analysis and a cross-sectional study were performed. The systematic review and meta-analysis were based on the PRISMA methodological guidelines. PubMed and Web of Science were searched using the descriptors: “bacterial vaginosis and HPV”, in June 2019. Inclusion criteria were original studies that investigated an association between BV and cervical HPV infection; published in English, Spanish or Portuguese; performed in young and adult women, over 15 years of age, non-pregnant, declared to be HIV negative, who used the Nugent criteria for the diagnosis of BV and PCR for the detection of HPV. Odds ratios (OR) and respective 95% confidence intervals (95% CI) were calculated for the association between BV and cervical HPV infection using random effects models. A value of p<0.05 was considered statistically significant. Six studies published between 2012 and 2019 were selected for analysis and demonstrated a significant association between BV and cervical HPV infection (OR: 2.68; 95% CI: 1.64-4.40; p<0.001). The cross-sectional study was carried out in a gynecology outpatient clinic of the public health network in Goiânia, Goiás. A total of 202 women were included and underwent gynecological examination, with cervical specimen collection. Cervical cytopathological exams, bacterioscopy and Nugent's criteria were performed for the diagnosis of BV and PCR and reverse hybridization for HPV detection and genotyping. By using bivariate analysis the association between BV and cervical HPV infection and between BV and cervical cytological abnormalities were investigated. The odds ratio was calculated, with the respective 95% confidence intervals (95% CI) and 5% significance level (p <0.05). The prevalence of BV was 33.2% (67/202), of cervical HPV infection was 38.6% (78/202) and of cervical cytological abnormalities was 6.0% (12/202). Bivariate analysis did not identify a significant association between BV and cervical HPV infection (OR: 0.69; 95% CI: 0.37-1.27; p=0.23), nor between BV and cervical cytological abnormalities (OR: 0.65; 95% CI: 0.17-2.50; p=0.54). In the systematic review and meta-analysis, BV was considered a risk factor for cervical HPV infection, however, in the cross-sectional study, BV was not associated with cervical HPV infection nor with cervical cytological abnormalities in the group of adult women investigated.Item Percepção discente do ambiente educacional de residência multiprofissional em hospital universitário(Universidade Federal de Goiás, 2020-03-04) Costa, Ana Carolina Arantes Coutinho; Pereira, Edna Regina Silva; http://lattes.cnpq.br/4503589425013098; Costa, Nilce Maria Silva Campos; http://lattes.cnpq.br/6977373149115047; Costa, Nilce Maria da Silva Campos; Marques, Flávio; Naghettini, Alessandra Vitorino; Mota, João Felipe; Batista, Sandro Rogério RodriguesINTRODUCTION: The educational environment has a significant impact on students' behavior and learning, being strongly related to satisfaction and success. Students are important elements in the quality of the educational environment, one of these being the residents. OBJECTIVE: To analyze the perceptions of the educational environment of the multidisciplinary health residency in a university hospital from the students' perspective. METHODS: The DREEM questionnaire was applied to all students in the multiprofessional residency program in health for the first and second years, with data analysis using the T-student test, Mann-Whitney and Kruskall Wallis. RESULTS: The total score was 85.23 (95% CI), which shows a more negative than positive educational environment. None of the 50 questions had a score above 3.5. 71.4% of the questions were identified as problematic. The three highest points are confident that I will pass this year, I have good friends on this course and I live in a comfortable place, the lowest three were: the teaching adopted is often stimulating, there is a good support program for stressed students and I rarely I feel discouraged in this course. CONCLUSIONS: The poor analysis of the educational environment, especially in the learning and social domains, may signal the need to review the educational structure of the residence as well as the creation of support for students who feel overwhelmed, stressed or unable to deal with their own insecurities and expectations as well as supporting the coping with the patient's health-disease process. A longitudinal analysis, with a larger sample or with a qualitative evaluation can also help to face the limitations of the study. The difficulties are similar to those faced by other multiprofessional residency programs in health, suggesting, therefore, that there is a systemic action by the Ministry of Health and also Brazilian Education.Item Retinol sérico, proteína ligante de retinol (RBP-4) e fatores de risco cardiometabólicos em crianças de 4 a 11 anos de idade(Universidade Federal de Goiás, 2020-02-06) Trindade, Neidiane Rosa; Silva, Maria Sebastiana; http://lattes.cnpq.br/1329422634395496; Silva, Maria Sebastiana; Silva, Gilberto Reis Agostinho; Santos, Renata Carvalho dos; Rebelo, Ana Cristina Silva; Guilho, Lidia AndreuBased on the hypothesis that children choose dyslipidemia, they present alterations in American retinol samples known as fat-soluble vitamins and antioxidants and that these variations can be used as cardiovascular risk. Therefore, the objectives of this study were to investigate the associations / influences of serum retinol and retinol binding protein (RBP-4) concentrations on risk factors and the cardiometabolic association. The study population included 212 children recruited from a public school in the city of Santo Antônio-Goiás for the study of serum retinol, and 36 were randomly selected for the RBP-4 study. The survey was conducted in 2018 and 2019. Height, body mass, waist circumference, blood pressure, lipoproteins and retinol serum were evaluated. Serum retinol concentrations were analyzed by high performance liquid chromatography. Regarding the correlation of retinol concentration with anthropometric variables, blood pressure and lipid profile, there was a positive association, cholesterol (r=0.25 p=0.001) and LDL (r=0.20 p=0.002). Logistic regression analysis with adjusted cholesterol found an association of retinol only in the group with hypercholesterolemia (β= -0.02) (p=0.015). In the comparative analysis it was observed that the 212 children with hypercholesterolemia had higher serum LDL-c concentrations (p< 0.001) total cholesterol (p< 0.001) retinol (p=0.020) e HDL-c (p=0.040). The results obtained from 36 children drawn showed similar dietary intake among those who had adequate cholesterol and hypercholesterolemia. In children with hypercholesterolemia, a positive association of RBP-4 with lipids was observed (p=0,049) and retinol (p= 0,013). Through multiple linear regression, it was found that for each 1g of lipid ingested, there was an increase of de 0.08 µmol/L de RBP-4 (β= 0.088 p=0.041) and for every 1 µmol / L retinol in the blood there is a 55.50 µmol / L increase in circulating RBP-4 (β= 55.50 p=0.0009). Conclusion: Children with hypercholesterolemia have cardiometabolic risk factors associated with serum retinol concentration and elevated RBP-4. Also, in children with hypercholesterolemia, RBP-4 was associated with retinol and dietary lipids.Item Determinação da espessura óssea entre o centro do forame apical e as superfícies externas das corticais na dentição permanente humana em imagens de tomografia computadorizada de feixe cônico(Universidade Federal de Goiás, 2018-12-19) Porto, Olavo Cesar Lyra; Silva, Júlio Almeida; http://lattes.cnpq.br/1022830186974104; Estrela, Carlos; http://lattes.cnpq.br/3611967334176683; Estrela, Carlos; Alencar, Ana Helena Gonçalves de; Pécora, Jesus Djalma; Silva, Júlio Almeida; Silva, Bruno Santos de FreitasThe aim of this study was to determine the thickness of the root apex in relation to cortical buccal and lingual / palatal human permanent teeth using computed tomography cone beam images (CBCT). A sample of 1,400 CBCT examination teeth from 422 patients (394 women, mean age of 44.46) was selected. The determination of the thickness of the apical foramen with the vestibular and lingual / palatal cortical was determined in CBCT images in the axial, coronal and sagittal sections, with reference to the center of the apical foramen and the external portion of the buccal and lingual / palatal cortical. The mean and standard deviation of the quantitative variables were obtained. The normality of the data was evaluated by the Kolmogorov-Smirnov test. Analysis of the comparison of independent samples was assessed by the t-Test for independent samples or by the Mann-Whitney Test. Values of p <0.05 were considered significant. The results showed that in the upper and lower anterior teeth the smaller bone thicknesses are directed towards the vestibular cortical. The lowest cortical vestibular thickness was found in the superior canine (1.49mm ± 0.86) followed by the upper central incisor (1.59mm ± 0.67). The greater cortical lingual / palatal thickness was found in the superior canine (8.63 ± 2.08) followed by the upper central incisor (7.07 ± 1.96). The lowest thickness was found in the cortex of the buccal root of the first (1.13 ± 0.68) and second (2.20 ± 1.21) premolars. The greatest cortical thickness lingual / palatal was found in the palatal cortex of the first (8.07 ± 1.63) followed by the second (7.62 ± 1.84) upper premolars. In the first upper molar the smallest thickness was found in the buccal cortical of the mesiobuccal root (1.98 ± 1.33). In the second lower molar, it was verified that the buccal cortical (8.36 ± 1.84) was thicker than the lingual cortical (2.95 ± 1.16). Knowledge of the anatomy of different dental groups and adjacent structures such as bone thickness of alveolar cortices influences the quality of surgical therapeutic planning, as well as guides the analysis of bacterial dissemination pathways in periapical infections. The CBCT allows to obtain linear measures that favor comparative analysis.Item Análise tridimencional da configuração radicular apical de dentes anteriores superiores(Universidade Federal de Goiás, 2019-10-31) Bernardes, Cristiane Martins Rodrigues; Estrela, Carlos; http://lattes.cnpq.br/3611967334176683; Estrela, Carlos; Silva, Brunno Santos de Freitas; Pécora, Jesus Djalma; Estrela, Cyntia Rodrigues de Araújo; Barletta, Fernando BrancoThis study analyzed the apical root configuration of maxillary anterior teeth using Cone-Beam Computed Tomography (CBCT) images in a Subpopulation of the Brazilian central region. A sample of 400 maxillary anterior teeth from 167 patients (101 women; mean age 41.8 years) from January 2012 to April 2017 was analyzed. The CBCT images used in this study were from a private dental radiology clinical database. The apical root configuration of the maxillary anterior incisors was verified by navigating 0.1 mm / 0.1 mm, in the three planes, axial, coronal and sagittal sections on CBCT images, from the root canal entrance to the apical foramen as well as from the apical direction to the crown. The standard reference for apical root shape configuration corresponded to the long axis of the tooth and when necessary, CBCT images were oriented to correct Parallax error. The determination of the root configuration of teeth and their frequency were characterized according to the classification of abnormalities in root morphology proposed by Levander & Malmgren, recorded in four categories: 1. short root; 2. blunt root; 3. root with apical bend (lacerated root); 4. pipette-shaped root. The frequency and percentage of qualitative variables were obtained and analyzed by the chi-square test. The level of significance was 5%. The most common apical root form presented in the central incisors was blunt root, followed by pipette-shaped root, lacerated root and, less frequently, blunt root. In the lateral incisors, the highest frequency presented was lacerated root, followed by blunt root, pipette-shaped root and, less frequently, short root.Item Determinação da distância da junção amelocementária à crista óssea alveolar decorridos onze anos do inicio do tratamento ortodôntico(Universidade Federal de Goiás, 2019-11-01) Castro, Luma Oliveira; Alencar, Ana Helena Gonçalves de; http://lattes.cnpq.br/2039898015468283; Estrela, Carlos; http://lattes.cnpq.br/3611967334176683; Estrela, Carlos; Alencar, Ana Helena Gonçalves de; Siqueira, Patrícia Correia de; Silva, Julio Almeida; Pecora, Jesus DjalmaObjective: The objective of the present study was to determine, by means of Cone-Beam Computed Tomography (CBCT) images, the distance between the cementoenamel junction and the alveolar bone crest in teeth undergoing orthodontic treatment after 11 years of follow-up. Methodology: Dental CBCT images of patients undergoing orthodontic treatment (T1) were selected from a database. The reference points for the measurements were the cementoenamel junction and the buccal and palatal / lingual alveolar bone crest, being determined by navigating the sagittal, axial and coronal sections. With the aid of the software, a vertical straight line was drawn between the two points, and the distance between the cementoenamel junction to the alveolar bone crest of the buccal (n = 379) and palatal / lingual (n = 379) faces obtained in millimeters. At follow-up after 11 years, the distance from the cementoenamel junction to the alveolar bone crest was again measured following the protocol previously described (T2). Results: After 11 years, there was an increase in the distance from the cementoenamel junction to the alveolar bone crest in all dental groups evaluated. From the total of 758 faces evaluated, 81% (614) presented increased distance when compared to the initial. The buccal face of the lower canines showed the highest frequency of enlargement (91%). In the initial sample, 117 (15%) faces presented a distance greater than 2 mm, while 11 years later, 327 (43%), and the canine buccal face was the one with the highest frequency. Conclusion: The results of the present study showed that 11 years after the beginning of orthodontic treatment, there was an increase in the distance from the cementoenamel junction to the alveolar bone crest in all dental groups evaluated.Item Multimorbidade em idosos brasileiros: prevalência, agrupamentos e redes de morbidades, continuidade de cuidado e utilização de serviços de saúde(Universidade Federal de Goiás, 2019-08-22) Batista, Sandro Rogério Rodrigues; Sousa, Ana Luiza Lima; http://lattes.cnpq.br/6578713509935374; Jardim, Paulo César Brandão Veiga; http://lattes.cnpq.br/2292209583823133; Jardim, Paulo César Brandão Veiga; Sousa, Ana Luiza Lima; Mendonça, Claunara Schilling; Thumé, Elaine; Trindade, Thiago GomesMultimorbity (MM), a simultaneous presence of two or more chronic diseases in the same individual, presents high prevalence and is related to important negative outcomes, especially in the elderly. Although frequent, the studies about MM are scarce. The aims of this study are to evaluate the presence of MM and associated factors, the presence of clusters/networking of morbidities and to analyze the potential effect of continuity of care in primary care (CCPC) in health services use among elderly people. Thus, we conducted the cross-sectional, population-based study using data from the National Health Survey (PNS-2013), with the analysis of 11,177 elderly people from all Brazilian states. MM was evaluated by the patient's self report, questionnaire for depression and anthropometric measurements, being categorized by three cut points: ≥2 physical and/or mental morbidities (MM2), ≥3 physical and/or mental morbidities (MM3) and ≥2 morbidities being at least one mental morbidity (MMpm). CCPC was analyzed by the presence of regular care source. The use of health services was analysed according to the demand for health services ≥15 days, medical consultation ≥12 months and hospitalization ≥1 year. Higher prevalence of MM was observed (MM2: 58.6%, MM3: 36.4%, MMpm: 12.2%). High blood pressure was the more frequent disease (50.6%), followed by back problems, high cholesterol and obesity. Hypertension/high cholesterol was teh par of higher occurrence (16.9%). In the adjusted analysis, being female and living in the South region was associated with all categories of MM. Independent of cutoff point, we observed elevated use of health services in the three categories analyzed. CCPC was present in 36.5%, being higher in women (37.78% vs. 34.95%). Less hospitalization was observed in people with MM2 and CCPC compared to those without CCPC, a fact also observed in MM3. Prevalence of MM in Brazilian series with high association with females and living in the South region. Our studies demonstrate that CCPC is an important component of care in elderly patients with multimorbity, aiming to reduce hospitalizations. Other studies are needed to clarify the different forms of CCPC that affect and strengthen services in health services. The Unified Health System should prioritize the care of the elderly with MM.Item Influência da intervenção musicoterapêutica sobre a variabilidade da frequência cardíaca e aspectos biopsicosociais em mães de prematuros: estudo randomizado(Universidade Federal de Goiás, 2019-06-10) Ribeiro, Mayara Kelly Alves; Silva, Tereza Raquel de Melo Alcântara; http://lattes.cnpq.br/5899812854673658; Rebelo, Ana Cristina Silva; http://lattes.cnpq.br/1542664015677213; Rebelo, Ana Cristina Silva; Silva, Tereza Raquel de Melo Alcântara; Mercadal Brotons, Melissa; Pansani, Aline Priscila; Barbosa, Maria AlvesBackground: Mothers of preterm infants often have symptoms of anxiety, depression, fatigue, and changes in quality of life. Anxiety and depression are recognized as risk factors for the development of cardiovascular diseases and are associated with low rates of Heart Rate Variability. These contribute to the imbalance of the Autonomic Nervous System and compromise neurocardial integrity. There is a paucity of studies that evaluate the influence of the interventional intervention in mothers in the Neonatal Intensive Care Unit on the autonomic control of heart rate. Heart Rate Variability has been described as a tool with important quantitative indices for the evaluation of the autonomic modulation of the Heart Rate. It is believed that the Music Therapy intervention promotes an increase in the Heart Rate Variability indexes and a decrease in the symptoms of depression, anxiety, fatigue and improvement of the quality of life. Objective: To analyze the influence of music therapy on the indexes of heart rate variability, anxiety, depression, quality of life and fatigue in mothers of severe preterm infants. Methodology: Randomized clinical trial with mothers of infants admitted to the Neonatal Intensive Care Unit of the Dona Iris Hospital and Maternity Hospital, Goiânia, Goiás, Brazil. The mothers (25.8 ± 4.5 years in the Music Therapy Group and 26.2 ± 7.1 years in the Control Group) were randomized in a control group and a group with interventional intervention on a weekly basis throughout the hospitalization period of the preterm infant. The participants were submitted to a sociodemographic questionnaire, Chalder's Fatigue Scale, Medical Outcomes Study 36-item Short-Form Health Survey, depression and anxiety scale (Beck scales); and uptake of Heart Rate Variability (for 15 minutes) after that moment the Music Therapy Group was submitted to the intervention and at the end of the hospitalization the reevaluation occurred. Results: The participants of the Music Therapy Group had an average of seven music therapy sessions and showed significant improvement in the Effect Size (0.519), depression (Effect Size: 0.483), quality of life in the pain (p = 0.006) and emotional well-being (p = 0.041) and autonomic indexes of the time domain (p <0.05). Negative and significant correlations were found between depression and parasympathetic modulation from the linear analysis (r = -0.687, p = 0.028) and non-linear (r = -0.689; p = 0.027) in the Music Therapy Group and among the different subdomains of Fatigue and Quality of life in both groups in the initial and final moments. Conclusion: Music therapy has been instrumental in reducing the symptoms of anxiety and depression, improving quality of life (pain and mental health) and parasympathetic modulation in mothers of premature infants. The results are relevant because they influence the emotional and neurocardic state and act in the prevention of the risk factors for the development of cardiovascular diseases.Item Rotulagem alimentar brasileira: uma nova proposta e seu impacto sobre a compreensão do consumidor(Universidade Federal de Goiás, 2017-06-07) Jacintho, Carolina Lôbo de Almeida Barros; Sousa, Ana Luiza Lima; http://lattes.cnpq.br/6578713509935374; Jardim, Paulo César Brandão Veiga; http://lattes.cnpq.br/2292209583823133; Jardim, Paulo César Brandão Veiga; Marques, Rosana de Morais Borges; Guimarães, Marília Mendonça; Jesuino, Rosália Santos Amorim; Santiago, Raquel de Andrade CardosoFood labels are poorly understood by most Brazilians, demonstrating an important reformulation requirement. Objective: This work aimed to compare the consumer's understanding of the traditional label versus a new food labeling proposal. Methods: a cross-sectional study carried out in 2016 in seven supermarkets in a Brazilian capital. Participants were all consumers aged 18 or over who were shopping at the time of data collection and went through the canning session. To evaluate the understanding of food labeling, the sample was divided into two groups: Group A observed the Current Label and Group P observed the Proposed Label. The participants answered a questionnaire with five questions related to the respective label analyzed and provided socioeconomic and health data. Student’s t and qui-square tests were used for comparison, with 5% significance level. Results: A total of 980 consumers were interviewed in seven supermarkets in a Brazilian capital, mean age of 38.2 ± 13.9 years, the majority female (57.1%), with high school degree (46.4%), family income between US$ 540 and US$1080 (33.4%), no diagnosis of chronic disease (84.8%) and Body Mass Index of 25.6 ± 4.7 kg/m². The label’s reading was affirmative for 54.1% of Group A and 93.3% of Group P. Nutrition facts understanding was satisfactory for 36.1% of Group A and 96.9% of Group P. When analyzing the current label, several participants gave incorrect answers regarding the sodium and sugar content of the product and this percentage was lower in the proposed label (p = 0.019 and p = 0.008, respectively). Because of the complex language, only 36.5% of the respondents reported that the current label helps purchase, as opposed to the proposed label, which percentage was 97.5%, with affirmations regarding greater didactics and easiness of comprehension. All responses had a significant difference when comparing groups (p<0.05) and the understanding of proposed label was statistically higher in comparison to current label (p=0.026). Conclusion: the consumers' understanding of the proposed label was significantly higher than the current label.Item Avaliação das moléculas HLA-G e PD-L1 em pacientes submetidos a transplante renal em Goiânia - GO(Universidade Federal de Goiás, 2020-09-11) Botelho, Silvia Marçal; Wastowski, Isabela Jubé; http://lattes.cnpq.br/4051434704701413; Silva, Nilzio Antonio da; http://lattes.cnpq.br/1780564621664455; Wastowski, Isabela Jubé; Reis, Ângela Adamski da Silva; Barbosa, Maria Alves; Sousa, Mauri Félix de; Barbosa, Vitalina de SouzaKidney transplantation (KT) is the treatment of choice for patients with end-stage renal disease. In KT, the HLA-G and PD-L1 molecules due to their tolerogenic action are of clinical and therapeutic interest. The aim of this study was to evaluate the HLA-G and PD-L1 molecules at different moments in the KT. 124 patients were evaluated. Of these, 114 were previously transplanted (Group of old patients-GOP) and, in 10 patients, the evaluation started in the pre-KT (Group of new patients-GNP). In the GOP a cross-sectional study with a single blood collection, while in the GPN a 12-month follow-up was carried out with serial blood collection. Patients who had graft dysfunction were submitted to renal biopsy samples and immunohistochemistry was performed for both molecules (GNP). The study execution phase took place from March/2016 to December/2017. In GOP the use of corticosteroids+calcineurin inhibitor +azathioprine as an initial immunosuppression regimen (p<0,001), the presence of one or two episodes of rejection (p <0,001), and CMV infection (p= ,006) were correlated with a low dosage of HLA-G. Having performed 6-10 hemodialysis sessions in post-KT was associated with a high dose of HLA-G (p=0,02). In GNP the occurrence of rejection episodes was associated with low expression of HLA-G (p<0,001) and PD-L1 (p<0,001). The variable time after KT (p<0,001) was associated with a lower level of HLA-G. Transfused patients had low levels of PD-L1 (p=0,03). Increased levels of HLA-G (p=0,001) and PD-L1 (p<0,001) were observed in female patients. Patients who received a kidney from a related live donor expressed more HLA-G (p<0,001). The study concluded that the aforementioned variables, which were positively and negatively associated with the levels of HLA-G and PD-L1 can promote the stability or instability of the grafts respectively, maintaining renal function or perhaps providing rejection processes.Item Associação dos genes FTO, DRD2 e ANKK1 com risco metabólico e efeito na obesidade pediátrica: estudo tipo caso controle(Universidade Federal de Goiás, 2020-07-06) Pinto, Renata Machado; Cruz, Aparecido Divino da; http://lattes.cnpq.br/7868817504129985; Curado, Maria Paula; http://lattes.cnpq.br/3397823736381748; Cruz, Aparecido Divino da; Minasi, Lysa Bernardes; Gigonzac, Thais Cidália Vieira; Costa, Paulo Sérgio Sucasas da; Marques, Solomar MartinsBackground: Obesity is a complex pathology, in which behavioral, endocrinological, metabolic, genetic and epigenetic factors interact. It is known that the genetic component is responsible for up to 70% of the variation in body mass index (BMI). Genetic polymorphisms that affect dopamine availability and secretion can alter the risk of obesity. Objectives: To determine the allele and genotype frequencies of the polymorphisms of FTO (rs9939609), DRD2 (rs6277) and ANKK1 (rs18000497) genes in children and adolescents from Goiás. To investigate the relationship between pediatric obesity, insulin sensitivity and cardiovascular risk factors (CRF) with the studied genes. Methods: Case-Control study conducted with adolescents and children over five years. The two main groups, Obese (O) and Eutrophic (E), were subdivided according to the value of HOMA-IR into Obese with insulin resistance (ORI) or insulin sensitivity (OSI) and Eutrophic resistant (ERI) or sensitive (ESI) to insulin. According to the presence of two or more CRF, they were subdivided into metabolically unhealthy (MU) or metabolically healthy (MH) groups: OMU, OMH, EMU, EMH. Polymorphisms were determined by real-time PCR or PCR-RFLP. The SPSS program was used for statistical calculations Results: The research assessed 124 obese and 102 eutrophic children and adolescents aged from 5 to 16 years. In the obese group, the higher the number of risk alleles of FTO and ANKK1 genes isolated and the three genes combined, the higher the mean BMI (p<0,0001). Regarding the FTO gene: the frequency of the risk allele was: 57.7%-ERI, 37.4%-ESI (p=0,048), and the homozygous wild genotype was: 29.5%-OMU, 37.5%-OMH (p=0,02). Regarding the DRD2 gene: the genotypes with the risk allele were present in 84.6%-OMU and 67.5%-OMH (p=0,031). Regarding the ANKK1 gene: the frequency of the homozygous risk genotype was current in 15.4%-ERI and 13.5%-ESI (p<0,0001) and 62.5%-EMU and 41.5%-OMH (p=0,031). Conclusions: The risk alleles of the FTO, DRD2 and ANKK1 genes showed an additive effect on the outcome of pediatric obesity in the population of Goiás. In eutrophic individuals, the ANKK1 and FTO genes were associated with insulin resistance. The presence of risk alleles of the ANKK1 and DRD2 genes increased the risk for FRCV in eutrophic and obese individuals, respectively, while the wild allele of the FTO gene had a protective effect for FRCV in obese individuals.Item Qualidade dos registros de enfermagem em prontuários após ação educativa em uma instituição pública de saúde(Universidade Federal de Goiás, 2017-12-04) Silva, Ludimila Cristina Souza; Prado, Marinésia Aparecida; http://lattes.cnpq.br/1151975582155991; Barbosa, Maria Alves; http://lattes.cnpq.br/5025797873585225; Barbosa, Maria Alves; Porto, Celmo Celeno; Brasil, Virginia Visconde; Prado, Marinésia Aparecida; Bezerra, Ana Lúcia QueirozRecords in hospitalized patients' records are important for the communication of health professionals for continuity of care, cost measurement, quality assessment, as well as providing legal actions for teaching and research. Objective: To evaluate the quality of nursing records in patient records after an educational action. Methodology: An analytical descriptive study performed in Neonatal, Maternal and Child Intensive Care Units, with analysis of 45 charts, before and after an educational intervention, which lasted eight hours. To evaluate the quality, the Nursing Annotations Audit Form (HADDAD, 2004) was used. After the data collection, the data were analyzed using the STATA software. Results: The main nonconformities found in the records were: incorrect or incomplete records, illegible letters or erasures and absence of records. Among the nonconformities was the inadequate completion of the cases evaluated before and after the educational intervention. However, the means inherent to complete, incomplete and unfilled information were significantly better after the educational intervention (p> 0.05). The categories, identification data (PP = 81.16%) and execution of medical orders (PP = 89.13%), presented higher adequacy indexes with respect to the complete records. However, the nursing prescription (PP = 6.76%) overcame the nonconformities in the question of incorrect filling of records in patients' records. Conclusion: The educational action signaled positive results regarding the effectiveness of records in medical records, evidencing the importance of qualification of health professionals. Based on these evidences, a permanent education program is recommended, with the objective of qualifying professionals regarding the requirements of the work process, such as the elaboration of standardized protocols, the habit of recording the actions in a complete and objective manner, printed, among other aspects. Intervention actions can raise awareness among professionals about competence, commitment to safety and continuous improvement of the quality of care provided to the patient.