AVALIAÇÃO DA RESPOSTA À VACINA BRASILEIRA CONTRA HEPATITE B (BUTANG®) EM RECÉM-NASCIDOS EM GOIÂNIA, GOIÁS
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Data
2009-03-03
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Universidade Federal de Goiás
Resumo
Hepatitis B vaccination is the major mode of hepatitis B prevention. To evaluate the
immunogenicity and reactogenicity of the Brazilian hepatitis B vaccine (Butang®) in
newborns in Goiania-GO, 294 infants born in the east of Goiânia, Goiás, were
recruited. All of them received the first vaccine dose in the first 12 hours of life. The
second and third doses were applied 30 and 150 days after, respectively. About 45
days after the last dose, blood samples were collected from 250 children in order to
detect quantitative anti-HBs, using the enzyme immunoassay of microparticles
(MEIA). All participants were evaluated 48-72 hours after each dose to investigate
local and systemic reactions. Mothers of newborns were screened for anti-HBs and
anti-HBc by enzyme immunoassay. Of 250 newborns who completed the study,
97.6% (95% CI: 94.8-99.1) developed anti-HBs protector titers, being most of them
higher than 100 mIU/mL (90,8%). The anti-HBs geometric mean titer was equal to
572 mIU/mL (95% CI: 471.1 - 694.6), and no difference was observed between
female and male newborns. Low responders NB (10-99 mIU/ml) were more frequent
in male infants (58,8% vs 41,2%). Maternal anti-HBs and/or anti-HBc-positivity did
not interfere in the newborns vaccine response. Concerning reactogenicity, only
induration (5.5%), redness (2.4%), heat (1.3%) and fever (12.9%) were observed
following the 829 vaccine doses applied. Six newborns did not respond to Butang®
vaccine. Of them, four were male. A booster dose was applied in all no vaccine
responders. All but one not developed anti-HBs protector titers following a booster
dose. The Butang® showed to be safe and immunogenic when administered to
newborns in the first 12 hours of life. However, more studies will be need to evaluate
its lifetime effectiveness.
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Citação
TAVARES, Viviane Rodrigues. EVALUATE OF BRAZILIAN HEPATITIS B VACCINE (BUTANG®)
RESPONDE IN NEWBORNS OF GOIÂNIA, GOIÁS. 2009. 69 f. Dissertação (Mestrado em Cuidado em Enfermagem) - Universidade Federal de Goiás, Goiânia, 2009.