Prevalência e fatores associados às infecções pelos vírus das hepatites B e C em pacientes HIV positivos, atendidos na rede pública de Goiânia - Goiás
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2013-05-06
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Universidade Federal de Goiás
Resumo
Hepatitis B and C viruses are responsible for the most common chronic viral infections
worldwide. The prevalence of these viruses is higher among HIV-infected individuals, due
to common route of transmission. Coinfections HBV / HIV and HCV / HIV seems to be
associated with a worst liver disease prognosis. Studies evaluating these coinfections in the
mid-western Brazil are scarce. Objectives: To estimate the prevalence and the risk factors
associated with HBV and HCV coinfections in HIV-positive patients in Goiânia – Goiás.
Methods: A cross-sectional study was conducted including 495 adults, recruited from the
Centro de Referência em Diagnóstico e Terapêutica de Goiânia in 2011. After signing the
informed consent, participants were interviewed and material was collected for research
markers for HBV (anti-HBc, HBsAg, anti-HBs and HBV DNA) and HCV (anti-HCV and
HCV RNA). Prevalence of HBV and HCV infection was estimated. Univariate and
multivariate analysis to evaluate factors associated with positivity for both viruses were
performed. Odds and adjusted odds ratios were calculated with 95% confidence intervals
(CI95%) and a significance level of p<0.05. Results: Participants mean age was 40.2
years (standard deviation =10. 4) with a male predominance (73.9%). Injecting drugs usage
was reported by 3.6% of participants. The prevalence of markers for hepatitis B exposure
was 33.5% (CI95% 29.4-37.9). Nineteen patients (3.8%, CI95% 2.4-6.0) were diagnosed
as hepatitis B carriers. Prevalence of anti-HCV was 9.7% (CI95% 7.3-12.7). The
distribution of HCV genotypes was: 1a (72.7%), 3 (13.6%) and 1b (9.1%). Coinfection by
the three viruses was 4.4% (CI95% 2.9-6.8). Male, age ≥ 40 years, previous history of
sexually transmitted disease (STD) and homo or bisexuality were associated with exposure
to HBV. History of injecting drugs and STD were associated with HCV seropositivity.
Over half of the coinfected patients were not aware of being HBV or HCV positive.
Conclusion: Seromarkers for previous HBV and/or HCV infections are common among
individual HIV positives in Goiânia. A significant proportion of them are unaware of their
serological status. These findings suggest the need for better screening and guidance
improvements for this population
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BRANDÃO, Natália Alberto Alves. Prevalência e fatores associados às infecções pelos vírus das hepatites B e C em pacientes HIV positivos, atendidos na rede pública de Goiânia - Goiás. 2013. Dissertação (Mestrado em Medicina Tropical e Saúde Pública) - Universidade Federal de Goiás, Goiânia, 2013.