Ação de um novo protótipo anti-hipertensivo (LASSBio897) sobre o sistema cardiovascular de cães
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2014-02-26
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Universidade Federal de Goiás
Resumo
In dogs, as in humans, arterial hypertension is characterized by an excessive
increase of systemic blood pressure which can cause renal, ocular, neurological
and cardiac lesions. Currently, five classes of antihypertensive agents are
commonly used. A drug prototype (LASSBio 897) capable of promoting
vasodilation effects was developed and became a possible alternative for new
therapeutic strategy. The main goal of this study was to investigate its vasodilatory
effect, as well as to identify possible changes in clinical, cardiovascular, renal and
hepatic functions. Six adult and healthy beagle dog were used. They received oral
doses of 0.5mg/kg, 1.0mg/kg and 2.0mg/kg of LASSBio 897 and 0.5mg/kg of
benazepril, as a positive control. Assessments of liver and kidney function, doppler
echocardiographic and electrocardiographic examinations and blood pressure
measurements, were performed. No clinical changes suggesting acute toxicity
were observed and all measured parameters were within the normal values for
canine species. Blood pressure values decreased gradually until time of 120min,
in which its lowest value was observed (120.58mmHg), among the three studied
doses, similar to that observed with benazepril. No hypotension or arrhythmias
were observed. In echocardiography, values of stroke volume and cardiac output
were lower than those described as normal for the species, with averages that
decreased until time of 240min. In conclusion the oral administration of the
prototype LASSBio 897, in single doses, causes vasodilation and is safe since no
significant changes in haematological, renal and hepatic biochemical evaluations
were observed, as well as in urinary review. The prototype does not cause side
effects, hypotension or abnormal heart rhythms.
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NASCIUTTI, Priscilla Regina. Ação de um novo protótipo anti-hipertensivo (LASSBio897) sobre o sistema cardiovascular de cães. 2014. 103 f. Dissertação (Mestrado em Ciência Animal) - Universidade Federal de Goiás, Goiânia, 2014.