Estresse oxidativo em bovinos confinados alimentados com feno de Brachiaria e suplementados com antioxidantes
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2014-11-01
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Universidade Federal de Goiás
Resumo
Oxidative stress is related to the development of different pathological processes.
Interventions that reduce the generation or the effects of free radicals have shown
controversial results in animal models. In this study, we evaluated the effects of
supplementation with different antioxidants through assessment of oxidative stress
biomarkers in erythrocytes (thiobarbituric acid reactive substances, superoxide dismutase,
glutathione full, glutathione peroxidase and catalase) in hepatocytes (malondialdehyde),
clinical laboratory tests and histological exam. 40 Nelore bovines were sorted into five
groups, as follows: one control without supplementation, three groups individually
supplemented with vitamin E, selenium and zinc and one group supplemented with the
combination of selenium and vitamin E. For 105 days, all animals were fed roughage
(brachiaria hay) and concentrate (feed) in a 70:30 ratio. The Biomarkers of oxidative stress
evaluation in erythrocytes did not indicate the presence of lipid peroxidation. In the liver,
supplementation with antioxidant selenium and vitamin E reduced the number of foamy
macrophages in the parenchyma, as well as tissue lipid peroxidation. The animals did not
develop clinical liver abnormalities throughout the experimental period, since aspartate
aminotransferase and gamma glutamyltransferase serum activity remained within normal
range. There was positive correlation between the concentration of the biomarker
malondialdehyde and foamy macrophages. In conclusion, feedlot cattle ingesting Brachiaria
sp present lipid peroxidation in hepatocytes and the combination of the antioxidants selenium
and vitamin E reduces the effects of oxidative stress.
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SILVA, R. D. Estresse oxidativo em bovinos confinados alimentados com feno de Brachiaria e suplementados com antioxidantes. 2014. 68 f. Tese (Doutorado em Ciência Animal) - Universidade Federal de Goiás, Goiânia, 2014.