2014-07-292010-05-112009-09-18BRUNO, Kely Firmino. Inflammatory and Immunological Aspects of pulpitis Human Dental. 2009. 83 f. Tese (Doutorado em Ciencias da Saude) - Universidade Federal de Goiás, Goiânia, 2009.http://repositorio.bc.ufg.br/tede/handle/tde/1562Immune and inflammatory cells may contribute to host defense and microenvironmental changes during the pathogenesis of dental pulpitis. This study evaluated the microscopic characteristics and densities (per mm2) of tryptase+ mast cells, CD4+ T helper lymphocytes, CD45RO+ memory T lymphocytes, foxp3+ T regulatory lymphocytes, CD20+ B lymphocytes, CD68+ macrophages, and CD31+ blood vessels in human dental pulpitis (n = 38). Methods: Tryptase, CD4, CD45RO, foxp3, CD20, CD68, and CD31 expressions were analyzed using immunohistochemistry; other microscopic features, such as intensity of inflammatory infiltrate and collagen deposition, were evaluated after staining with hematoxylin and eosin. Results: Two microscopic patterns of dental pulpitis were found: group 1 (G1) (n = 15) showed intense inflammatory infiltrate and mild collagen deposition; conversely, group 2 (G2) (n = 23) showed scarce inflammatory infiltrate and intense collagen deposition. The numbers of CD68+ and CD20+ cells and the density of blood vessels were higher in G1 than in G2. However, there were no differences in CD4+ and CD45RO+ cell densities between groups. When present, mast cells were equally distributed in G1 and G2, whereas foxp3+ cells were detected in 58.82% and 14.28% of the samples of G1 and G2. Conclusions: Immune and inflammatory cell infiltration have different patterns in human dental pulpitis, which might reflect distinct microscopic characteristics and particular local defense capabilities.application/pdfAcesso AbertoPolpa dentáriapulpite dentáriacélulas inflamatóriascélulas imunológicascárieDental pulpdental pulpitisinflammatory cellsimmunological cellscaries1.Polpa dentária 2.Pulpite dentária 3.Cárie 4.Células inflamatórias 5.Células imunológicaCNPQ::CIENCIAS DA SAUDETese