Desenvolvimento e caracterização de carreador lipídico nanoestruturado contendo leflunomida
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Data
2023-08-02
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Universidade Federal de Goiás
Resumo
Rheumatoid arthritis (RA) is an autoimmune disease characterized by deformation and destruction of peripheral joints. One of the drugs indicated for its treatment is leflunomide (LEF). There are strategies that can be adopted to improve the low aqueous solubility of the drug and minimize its systemic adverse effects (gastrointestinal symptoms, allergic reactions alopecia, skin eruptions, opportunistic infections and arterial hypertension), such as nanoencapsulation and local administration. This project aimed to develop nanostructured lipid carriers (NLC) and to evaluate their physicochemical characteristics, storage stability, kinetic stability and encapsulation efficiency. The method of emulsification and solvent evaporation associated with microfluidization was used. In the physical-chemical characterization and in the stability study, the average size and polydispersity index (PdI) were evaluated through dynamic light scattering (DLS). The kinetic stability of NLC was evaluated through multiple light scattering. The encapsulation efficiency was determined using the indirect method, quantifying the concentration of free drug present in the formulation. The formation of nanometric and homogeneous particles (average size of 213 nm and PdI of 0.239) was observed. The NLC showed low backscattering variation (∆BS), less than 2%, and encapsulation efficiency of 73.3% ± 9.1. The preparation method by emulsification and solvent evaporation obtained systems with appropriate characteristics for future in vitro studies of release and cutaneous permeation of nanoencapsulated LEF.
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Leflunomida, Artrite reumatoide, Nanoencapsulação, Nanopartícula lipídica, Leflunomide, Rheumatoid arthritis, Nanoencapsulation, Lipid nanoparticle
Citação
NAKAMURA, Juliana Midori. Desenvolvimento e caracterização de carreador lipídico nanoestruturado contendo leflunomida. 2023. 33 f. Trabalho de Conclusão de Curso (Graduação) – Faculdade de Farmácia, Universidade Federal de Goiás, Goiânia, 2023.