Câncer de endométrio: o papel da terapia adjuvante
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Data
2024-06-27
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Universidade Federal de Goiás
Resumo
Introduction: Endometrial cancer (EC) is one of the most common forms of gynecological cancer, significantly impacting women's health and an estimate of around 8.000 new cases in 2022 according to INCA (National Cancer Institute). This study investigates the current treatment approaches for women with endometrial cancer, with a particular attention to adjuvant therapy. Objective: The main objective is to understand the current landscape of adjuvant therapy in the management of endometrial neoplasia. Methodology: For the construction of the integrative literature review, a search was conducted in the SCIELO, PUBMED, and LILACS databases in January 2024, using the following descriptors: Endometrial Cancer, Treatment, Diagnosis, Management, Therapeutics, Endometrial Neoplasms, Câncer de Endométrio, Manejo, and Tratamento. Results: The search resulted in a total of 1.828 articles, of which 40 were selected based on the reading of titles and abstracts. From these, 18 texts were chosen for full reading, and finally, 9 were included. According to the evidence found, adjuvant therapy is recommended for patients at intermediate and high risk. In high-risk cases, combined chemotherapy can improve progression-free survival; however, the necessity must be evaluated individually. In advanced endometrial cancer, chemotherapy with Carboplatin and Paclitaxel is standard, but caution is needed due to toxicity, especially when associated with Doxorubicin. Regarding hormonal therapy, its effectiveness as an adjuvant is still unclear. Conclusion: Although the primary treatment for EC is surgical, adjuvant therapy plays a crucial role in patient prognosis, involving modalities such as chemotherapy, brachytherapy,
radiotherapy, and hormone therapy. Additionally, given the increasing incidence of endometrial cancer, there is an urgent need for more research to improve the management and adjuvant therapy, given the variations in observed prognoses.
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Câncer, Endométrio, Terapia adjuvante, Tratamento, Cancer, Endometrium, Adjuvant therapy, Treatment
Citação
ANJOS, Daniela dos Santos; SILVA, Haila Cristina do Rêgo; PEREIRA, Isabella Victória Silva; RAMOS, Marina Matos. Câncer de endométrio: o papel da terapia adjuvante. 2024. 41 f. Trabalho de Conclusão de Curso (Bacharelado em Medicina) – Faculdade de Medicina, Universidade Federal de Goiás, Goiânia, 2024.