Avaliação da eficácia do ivermectin na larva migrans murina experimental
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Data
1993-06
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Editor
Ruy de Souza Lino Junior
Resumo
Sixty-eight inbred mice C57BL/6 wcre orally iníectcd wilh IO3 embryonatcd
eggs of Toxocara canis to evaluate thc cíícct of differcnt doses of Ivermectin.
Groups I(n=18), II(n=10) and III(n=10) wcre trcated with 200, 400 and 800 ug of
Ivermectin, respectively, and Groups IV(n=20) and V(n=10) wcre controls. The T.
canis eggs were obtained from lhe proximal utcrus of pregnant parasites, and were
incubated at room tcmperature in 1% of fonnaldehyde for 40 days, in order to obtain
infcctive embryonated eggs. Ivermectin was adininistered to thc experimental group
by subcutaneous route aftcr dilution in propilcnoglicol, cight days after inoculation.
Ali animais were euthanatized 23 days aftcr inoculation, at which time samples of
brain and eyes tissues wcre histologically cxaminaled by means of vitropressure
using normal light microscopy (for parasitological cvaluation). Efficacy was 54.02%,
54.76% and 55.44% for treatcd groups wilh 200, 400 and 800 ug of Ivermectin,
rcspcctively. Despite of the small sample sizc of lhe experimental groups, lhe present
data support lhat the treatment regimens of Ivermectin used had litlle efficacy for
experimental visceral larva migrans of mice.
Descrição
Palavras-chave
Larva migrans visceral, Toxocara canis, Ivermectin, Visceral larva migrans
Citação
VIEIRA, Miguel Alípio; SILVA, Andréa Caetano; FREIRE FILHA, Lindomar Guedes; BARBOSA, Carlos Augusto Lopes; CAMPOS, Dulcinéa Maria Barbosa. Avaliação da eficácia do ivermectin na larva migrans murina experimental. Revista de Patologia Tropical, Goiânia, v. 22, n.1, p. 23-27, jan./jun. 1993. Disponível em: <https://www.revistas.ufg.br/iptsp/article/view/20063/11655>.