Cisticercose: fatores relacionados a interação parasito-hospedeiro, diagnóstico e soroprevalência
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Data
2000-05
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Editor
Ruy de Souza Lino Junior
Resumo
Cysticercosis is a disease characterized by the presence of the metacestoda
larval form of Taenia solium in human tissues, caused by the accidental
ingestion of viable eggs present in faecal material of individuais who carry
the adult worm. The Central Nervous System is the most importam disease
site due to the severity of symptoms, disease polymorphism and the
difficulties involved with diagnosis. The disease course is determined by the
immune and inflammatory mechanisms generated by the host/parasite
interaction, which occurs at different degrees of complexity, resulting from
the activation and migration of the oncospheres through the lumen of the
small intestine and from larval implantation and survival in host tissues. The
stage of development, number and localization of the cysticerci determine
disease symptoms and will influence immunological and radiologic
diagnosis. Defmitive diagnosis can only be established through parasite
demonstration in a given specimen but technical difficulties and the invasive
nature of procedures lead to presumptive diagnosis in most of the cases.
Radiologic methods such as an brain computed tomography scan and magnetic resonance imaging are of limited use in developing countries due to
high cost and restricted availability. The detection of antibodies against the
larval form of Taenia solium is recommended for symptomatic individuais
and is widely used in seroepidemiological studies. Due to the high sensitivity
and specificity, the enzyme-linked immunosorbent assay and the enzymelinked
immunoelectrotransfer tests are largely employed. Data from
developing countries show increasing numbers of cysticercosis cases, with
high frequency among imigrants from México and South Ásia. Few studies
related to cysticercosis frequency have been published whereas heterogeneity
of the serological tests currently used compromise an accurate estimate of
cysticercosis prevalence. In developing countries, the prevalence of
antibodies anti- Cysticercus cellulosae ranges from 1% to 21%. In Brazil,
studies are limited to few states and most are restricted to cysticercosis active
cysticercosis disease, observed in neurology centers and anatomopathological
reports from general and psychiatric hospitais.
Descrição
Palavras-chave
Cisticercose, Diagnóstico, Neurocisticercose, Epidemiologia, Soroprevalência, Taenia solium, Cysticercus cellulosae, Imunodiagnóstico, Cysticercosis, Diagnosis, Neurocysticercosis, Epidemiology, Seroprevalence, Immunodiagnosis
Citação
BARBOSA, Alverne Passos; COSTA-CRUZ, Júlia Maria; SILVA, Simonne Almeida e; CAMPOS, Dulcinéa Maria Barbosa. Cisticercose: fatores relacionados a interação parasito-hospedeiro, diagnóstico e soroprevalência. Revista de Patologia Tropical, Goiânia, v. 29, n. 1, p. 17-34, jan./jun. 2000. Disponível em: <https://www.revistas.ufg.br/iptsp/article/view/16345/9956>.