Avaliação de citocinas em secreção endocervical de mulheres com candidíase, tricomoníase ou vaginite bacteriana
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Data
2011-05
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Editor
Ruy de Souza Lino Junior
Resumo
Infectious processes in the vagina due to infectious micro-organisms are very
common. Vulvovaginitis is commonly caused by protozoa, yeasts, bacteria and/or
viruses and their eradication or containment are usually mediated by cytokines of
the vaginal mucosa. In this study, the intention was to measure the concentration of cytokines IL-2, IL-6, IL-10, IL-12, IFN-γ and TNF-α and their relationship with
some of the infections. One-hundred and seventy three women were included, with
ages between 16 and 48 years (mean=31.4 ± 6.5 years). They were distributed
into four groups: control, candidiasis, trichomoniasis and bacterial vaginitis
group. The samples were subsequently submitted to culture and identification of
micro-organism, followed by cytokine measurements. The data was submitted to
statistical analysis. Median, interquartile range and the Mann-Whitney test was
employed and considered significant when p<0.05. The levels of cytokines in the
lower genital-tract of women with candidiasis, trichomoniasis, bacterial vaginitis
were higher than those with normal flora. Sixty (34.7%) women were in the control
group, 19 (11.0%) presented only candidiasis, three (1.7%) presented trichomoniasis,
and only ten presented (5.8%) bacterial vaginosis. The remaining participants had
comorbidities such as HPV or bacterial vaginosis, although the study of these last
two or association with other conditions was not performed. IL-2 and IL-12 were
significantly elevated in the presence of candidiasis, compared with the control group
p=0.01 and p=0.07, respectively. Patients with bacterial vaginitis also had statistically
significant increased levels for IL-2 (p=0.03) and for IL-12 (p=0.04). TNF-α was
elevated only in the presence of trichomoniasis p=0.04. We concluded that patients
with vaginal infections had an increase in the concentrations of some cytokines.
Descrição
Palavras-chave
Candidíase, Tricomoníase, Vulvovaginites., Citocinas, Candidiasis, Trichomoniasis, Vulvovaginitis Cytokines
Citação
CAMPOS, Ana Claudia Camargo; MURTA, Eddie Fernando Candido; MICHELIN, Márcia Antoniazi; PAULINELLI, Régis Resende; REIS, Cleômenes. Avaliação de citocinas em secreção endocervical de mulheres com candidíase, tricomoníase ou vaginite bacteriana. Revista de Patologia Tropical, Goiânia, v. 40, n. 2, p. 125-136, abr./jun. 2011. Disponível em: <https://www.revistas.ufg.br/iptsp/article/view/14938/9291>.