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http://repositorio.bc.ufg.br/handle/ri/14174| Tipo do documento: | Artigo |
| Título: | Parasite persistence in treated chagasic patients revealed by xenodiagnosis and polymerase chain reaction |
| Autor: | Britto, Constança Silveira, Celeste Cardoso, Maria Angelica Marques, Patricia Ostermayer, Alejandro Luquetti Macêdo, Vanize Fernandes, Octavio |
| Resumo: | Polymerase chain reaction (PCR) was compared with xenodiagnosis performed 20 years after trypanocidal chemotherapy to investigate parasite clearance. Eighty-five seropositive individuals for Chagas disease presenting a positive xenodiagnosis were treated with specific drugs; 37 in the acute phase and 48 in the chronic phase. Fifteen chronic assymptomatic patients received a placebo. Treatment in the acute phase led to PCR negative results in 73% of the cases, while xenodiagnosis was negative in 86%. In the chronic phase, PCR was negative in 65% of the patients and 83% led to xenodiagnosis negative results. Regarding the untreated group (placebo), 73% gave negative results by xenodiagnosis, of which 36% were positive by PCR. Individuals that were considered seronegative (n=10), presented unequivocally negative results in the PCR demonstrating the elimination of parasite DNA. Seventeen individuals had their antibodies titers decreased to such a level that the final results were considered as doubtful and 16 of them presented negative PCR. The molecular method represents a clear advantage over conventional techniques to demonstrate persistent infections in Chagas disease patients that underwent chemotherapy. |
| Palavras-chave: | Trypanosoma cruzi Kinetoplast DNA Chagas disease PCR Treatment |
| País: | Brasil |
| Unidade acadêmica: | Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG) |
| Citação: | BRITTO, Constança; SILVEIRA, Celeste; CARDOSO, Maria Angelica; MARQUES, Patricia; LUQUETTI, Alejandro; MACÊDO, Vanize; FERNANDES, Octavio. Parasite persistence in treated chagasic patients revealed by xenodiagnosis and polymerase chain reaction. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 96, n.6, p. 823-826, Aug. 2001. |
| Tipo de acesso: | Acesso Aberto |
| Identificador do documento: | 10.1590/S0074-02762001000600014 |
| Identificador do documento: | 10.1590/S0074-02762001000600014 |
| URI: | http://repositorio.bc.ufg.br/handle/ri/14174 |
| Data de publicação: | Ago-2001 |
| Aparece nas coleções: | FM - Artigos publicados em periódicos |
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| Arquivo | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| Artigo - Constança Britto - 2001.pdf | 40,17 kB | Adobe PDF |  Baixar/Abrir |
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