Isotretinoína: perfis farmacológico, farmacocinético e analítico
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Data
2002-12
Autores
Diniz, Danielle Guimarães Almeida
Lima, Eliana Martins
Antoniosi Filho, Nelson Roberto
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Resumo
Isotretinoin, or 13-cis-retinoic acid, is one of the vitamin A
related compounds. Isotretinoin is used for the treatment of
severe cystic acne and also shows inhibitory activity over
the proliferation of neoplasic cells, due to its efficiency in regulating cell diferentiation. Side effects are related to skin
and mucous membranes, central nervous system, muscles,
lymphatic, gastrintestinal, pulmonary and genitourinary
systems. Isotretinoin is a highly thermal and photolabile
compound. Stability studies require several analytical
methods such as HPLC, GC, thermal analysis, mass spectrometry, microcalorimetry and X-Ray difratometry.
Descrição
Palavras-chave
Isotretinoína, CLAE, Estabilidade química, Usos terapêuticos, Efeitos adversos, Isotretinoin, HPLC, Stability, Therapeutic uses, Side effects
Citação
DINIZ, Danielle Guimarães Almeida; LIMA, Eliana Martins; ANTONIOSI FILHO, Nelson Roberto. Isotretinoína: perfis farmacológico, farmacocinético e analítico. Revista Brasileira de Ciências Farmacêuticas, São Paulo, v. 38, n. 4, p. 415-430, out./dez. 2002.