Matrix metalloproteinases 2 and 9 expression in canine normal prostate and with proliferative disorders
Carregando...
Data
2013-06
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
In this study the expression of metalloproteinases 2
(MMP-2) and 9 (MMP-9) in canine normal prostates and with
proliferative disorders was evaluated to verify the role of these
enzymes in extracellular matrix remodeling (ECM) and in the
tissue invasion process. A total of 355 prostatic samples were
obtained, from which 36 (10.1%) were normal prostates, 46
(13.0%) with benign prostatic hyperplasia (BPH), 128 (36.1%)
with proliferative inflammatory atrophy (PIA), 74 (20.8%)
with prostatic intraepithelial neoplasia (PIN), and 71 (20.0%)
with prostatic carcinoma (PC). Difference in cytoplasmic
immunohistochemical staining of MMP-2 and MMP-9 between
acinar epithelium and periacinar stroma was found regarding
the different diagnosis. The correlation between MMP-2 and
MMP-9 expression in relation to the number of labeled cells
in acinar epithelium and periacinar stroma, as well as to the
staining intensity in the periacinar stromal cells was evidenced
in canine prostates with PIA. In conclusion, MMP-2 and MMP-
9 expression has a variation in canine prostate according to the
lesion, with lower expression in normal tissue and with BPH, and
higher expression in those with PIA, PIN and PC. Moreover, the
inflammatory microenvironment of the PIA has influence in the
activity of both enzymes.
Descrição
Palavras-chave
Cão, Gelatinases, Hiperplasia prostática benigna, Atrofia inflamatória proliferativa, Neoplasia intraepitelial prostática, Carcinoma prostático, Dog, Gelatinases, Benign prostatic hyperplasia, Proliferative inflammatory atrophy, Prostatic intraepithelial neoplasia, Prostatic carcinoma
Citação
FALEIRO, Mariana Batista Rodrigues; CROCE, Giuliana Brasil; TOLEDO, Denise Caroline; RODRIGUES, Marcela Marcondes Pinto; BATISTA, Aline Carvalho; DAMASCENO, Adilson Donizetti; BRITO, Luiz Augusto Batista; AMORIM, Renée Laufer; MOURA, Veridiana Maria Brianezi Dignani de. Matrix metalloproteinases 2 and 9 expression in canine normal prostate and with proliferative disorders. Ciência Rural, Santa Maria, v. 43, n. 6, p. 1037-1043, jun. 2013.