Caracterização histomorfológica da atrofia inflamatória proliferativa na próstata canina
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Data
2010-06
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Resumo
Proliferative inflammatory atrophy (PIA) is a
premalignant prostatic change with high occurrence in human
prostate and it has been recently observed in dogs. This research
aimed to verify the morphologic aspects of the PIA in canine
prostate. It was studied 43 glands of adult dogs of several
breeds and sizes and with or without a history of prostatic
disease. PIA focus was characterized by dysplastic epithelium,
atrophic acini formed by several layers of cells with variable
degrees of anisocytosis, anisokaryosis, reduced amount of
cytoplasm and nuclei with prominent nucleoli. The epithelial
changes were always accompanied by periacinar interstitial
infiltrate composed of mononuclear cells, especially
lymphocytes. The histomorphological evaluation showed
occurrence of 65% of PIA. Out of these, 39% were PIA with
discrete inflammatory infiltration, 42% PIA with moderate
infiltrate and 19% PIA with marked infiltration. Thus, it was
possible to characterize the PIA in the canine prostate which
had high occurrence. The histomorphological characterization
of canine PIA is considered of great importance because the
premalignant characteristic of it have been studied in human
prostate. The canine prostate can be used as an experimental
model of human PIA, because the lesion is similar in both
species.
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Palavras-chave
Cão, PIA, Displasia prostática, Dog, Prostatic dysplasia
Citação
TOLEDO, Denise Caroline; FALEIRO, Mariana Batista Rodrigues; RODRIGUES, Marcela Marcondes Pinto; SANTIS, Giovana Wingeter di; AMORIM, Renée Laufer; MOURA, Veridiana Maria Brianezi Dignani de. Caracterização histomorfológica da atrofia inflamatória proliferativa na próstata canina. Ciência Rural, Santa Maria, v. 40, n. 6, p. 1372-1377, jun. 2010.