Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/15111
Tipo do documento: Artigo
Título: Evaluation of Haemophilus influenzae type b carrier status among children 10 years after the introduction of Hib vaccine in Brazil
Autor: Zanella, Rosemeire Cobo
Brandileone, Maria Cristina de Cunto
Andrade, Ana Lúcia
Ogassavara, Cinthya Terumi
Fiório, Cleiton Eduardo
Brandão, Angela Pires
Almeida, Samanta Cristine Grassi
Lemos, Ana Paula Silva
Gorla, Maria Cecília
Carvalhanas, Telma Regina
Sato, Helena
Liphaus, Bernadete
Nerger, Maria Lígia
Conde, Monica
Ribeiro, Ana Freitas
Abstract: The aim of the present study was to assess the prevalence of Haemophilus influenzae type b (Hib) nasopharyngeal (NP) colonisation among healthy children where Hib vaccination using a 3p+0 dosing schedule has been routinely administered for 10 years with sustained coverage (> 90%). NP swabs were collected from 2,558 children who had received the Hib vaccine, of whom 1,379 were 12-< 24 months (m) old and 1,179 were 48-< 60 m old. Hi strains were identified by molecular methods. Hi carriage prevalence was 45.1% (1,153/2,558) and the prevalence in the 12-< 24 m and 48-< 60 m age groups were 37.5% (517/1,379) and 53.9% (636/1,179), respectively. Hib was identified in 0.6% (16/2,558) of all children in the study, being 0.8% (11/1,379) and 0.4% (5/1,179) among the 12-< 24 m and 48-< 60 m age groups, respectively. The nonencapsulate Hi colonisation was 43% (n = 1,099) and was significantly more frequent at 48-< 60 m of age (51.6%, n = 608) compared with that at 12-< 24 m of age (35.6%, n = 491). The overall resistance rates to ampicillin and chloramphenicol were 16.5% and 3.7%, respectively; the co-resistance was detected in 2.6%. Our findings showed that the Hib carrier rate in healthy children under five years was very low after 10 years of the introduction of the Hib vaccine.
Palavras-chave: Brazil
Haemophilus influenzae type b
Nasopharyngeal carriage
Hib conjugate vaccine
País: Brasil
Unidade acadêmica: Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
Citação: ZANELLA, Rosemeire Cobo et al. Evaluation of Haemophilus influenzae type b carrier status among children 10 years after the introduction of Hib vaccine in Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 110, n. 6, p. 755-759, 2015.
Tipo de acesso: Acesso Aberto
URI: http://repositorio.bc.ufg.br/handle/ri/15111
Data de publicação: 2015
Aparece nas coleções:IPTSP - Artigos publicados em periódicos

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