Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/15194
Tipo do documento: Artigo
Título: The endothelin system has a significant role in the pathogenesis and progression of Mycobacterium tuberculosis infection
Autor: Correa, André França
Bailão, Alexandre Melo
Charneau, Izabela Marques Dourado Bastos
Orme, Ian M.
Soares, Célia Maria de Almeida
Kipnis, Andre
Santana, Jaime Martins de
Ana Paula, Junqueira-Kipnis
Abstract: Tuberculosis (TB) remains a major global health problem, and although multiple studies have addressed the relationship between Mycobacterium tuberculosis and the host on an immunological level, few studies have addressed the impact of host physiological responses. Proteases produced by bacteria have been associated with important alterations in the host tissues, and a limited number of these enzymes have been characterized in mycobacterial species. M. tuberculosis produces a protease called Zmp1, which appears to be associated with virulence and has a putative action as an endothelin-converting enzyme. Endothelins are a family of vasoactive peptides, of which 3 distinct isoforms exist, and endothelin 1 (ET-1) is the most abundant and the bestcharacterized isoform. The aim of this work was to characterize the Zmp1 protease and evaluate its role in pathogenicity. Here, we have shown that M. tuberculosis produces and secretes an enzyme with ET-1 cleavage activity. These data demonstrate a possible role of Zmp1 for mycobacterium-host interactions and highlights its potential as a drug target. Moreover, the results suggest that endothelin pathways have a role in the pathogenesis of M. tuberculosis infections, and ETA or ETB receptor signaling can modulate the host response to the infection. We hypothesize that a balance between Zmp1 control of ET-1 levels and ETA/ ETB signaling can allow M. tuberculosis adaptation and survival in the lung tissues.
País: Estados unidos
Unidade acadêmica: Instituto de Ciências Biológicas - ICB (RG)
Citação: CORREA, André F. et al. The endothelin system has a significant role in the pathogenesis and progression of Mycobacterium tuberculosis infection. Infection and Immunity, Washington, v. 82, n.12, p. 5154-5165, 2014.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1128 /IAI.02304-14
Identificador do documento: 10.1128 /IAI.02304-14
URI: http://repositorio.bc.ufg.br/handle/ri/15194
Data de publicação: 2014
Aparece nas coleções:IPTSP - Artigos publicados em periódicos

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