Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/15220
Tipo do documento: Artigo
Título: Direct effect of 10-valent conjugate pneumococcal vaccination on pneumococcal carriage in children Brazil
Autor: Andrade, Ana Lúcia Sampaio Sgambatti de
Ternes, Yves Mauro Fernandes
Vieira, Maria Aparecida da Silva
Garcia, Weslley José Moreira
Cardoso, Juliana Lamaro
Kipnis, André
Cardoso, Maria Regina Alves
Brandileone, Maria Cristina de Cunto
Moura, Iaci
Pimenta, Fabiana Cristina
Carvalho, Maria da Gloria
Saraiva, Fabricia Oliveira
Toscano, Cristiana Maria
Minamisava, Ruth
Abstract: Background: 10-valent conjugate pneumococcal vaccine/PCV10 was introduced in the Brazilian National Immunization Program along the year of 2010. We assessed the direct effectiveness of PCV10 vaccination in preventing nasopharyngeal/ NP pneumococcal carriage in infants. Methods: A cross-sectional population-based household survey was conducted in Goiania Brazil, from December/2010- February/2011 targeting children aged 7–11 m and 15–18 m. Participants were selected using a systematic sampling. NP swabs, demographic data, and vaccination status were collected from 1,287 children during home visits. Main outcome and exposure of interest were PCV10 vaccine-type carriage and dosing schedules (3p+0, 2p+0, and one catch-up dose), respectively. Pneumococcal carriage was defined by a positive culture and serotyping was performed by Quellung reaction. Rate ratio/RR was calculated as the ratio between the prevalence of vaccine-types carriage in children exposed to different schedules and unvaccinated for PCV10. Adjusted RR was estimated using Poisson regression. PCV10 effectiveness/VE on vaccine-type carriage was calculated as 1-RR*100. Results: The prevalence of pneumococcal carriage was 41.0% (95%CI: 38.4–43.7). Serotypes covered by PCV10 and PCV13 were 35.2% and 53.0%, respectively. Vaccine serotypes 6B (11.6%), 23F (7.8%), 14 (6.8%), and 19F (6.6%) were the most frequently observed. After adjusted for confounders, children who had received 2p+0 or 3p+0 dosing schedule presented a significant reduction in pneumococcal vaccine-type carriage, with PCV10 VE equal to 35.9% (95%CI: 4.2–57.1; p = 0.030) and 44.0% (95%CI: 14.–63.5; p = 0.008), respectively, when compared with unvaccinated children. For children who received one catch-up dose, no significant VE was detected (p = 0.905). Conclusion: PCV10 was associated with high protection against vaccine-type carriage with 2p+0 and 3p+0 doses for children vaccinated before the second semester of life. The continuous evaluation of carriage serotypes distribution is likely to be useful for evaluating the long-term effectiveness and impact of pneumococcal vaccination on serotypes reduction.
País: Estados unidos
Unidade acadêmica: Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
Citação: ANDRADE, Ana Lucia et. al. Direct effect of 10-valent conjugate pneumococcal vaccination on pneumococcal carriage in children Brazil. Plos One, San Francisco, v. 9, n. 6, e98128, 2014.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1371/journal.pone.0098128
Identificador do documento: 10.1371/journal.pone.0098128
URI: http://repositorio.bc.ufg.br/handle/ri/15220
Data de publicação: 2014
Aparece nas coleções:IPTSP - Artigos publicados em periódicos

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