Effect of magnetic dipolar interactions on nanoparticle heating efficiency: implications for cancer hyperthermia
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2013-10
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Nanostructured magnetic systems have many applications, including potential use in cancer therapy
deriving from their ability to heat in alternating magnetic fields. In this work we explore the influence of
particle chain formation on the normalized heating properties, or specific loss power (SLP) of both low-
(spherical) and high- (parallelepiped) anisotropy ferrite-based magnetic fluids. Analysis of ferromagnetic
resonance (FMR) data shows that high particle concentrations correlate with increasing chain length
producing decreasing SLP. Monte Carlo simulations corroborate the FMR results. We propose a theoretical
model describing dipole interactions valid for the linear response regime to explain the observed trends.
This model predicts optimum particle sizes for hyperthermia to about 30% smaller than those previously
predicted, depending on the nanoparticle parameters and chain size. Also, optimum chain lengths depended
on nanoparticle surface-to-surface distance. Our results might have important implications to cancer
treatment and could motivate new strategies to optimize magnetic hyperthermia.
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Colloids, Nanotechnology in cancer, Cancer therapy, Magnetic properties and materials
Citação
BRANQUINHO, Luis C.; CARRIÃO, Marcus S.; COSTA, Anderson S.; ZUFELATO, Nícholas; SOUSA, Marcelo H.; MIOTTO, Ronei; IVKOV, Robert; BAKUZIS, Andris F. Effect of magnetic dipolar interactions on nanoparticle heating efficiency: implications for cancer hyperthermia. Scientific Reports, London, v. 3, p. 2887, 2013.