Antiprotozoal alkaloids from Psychotria prunifolia (Kunth) steyerm
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Data
2012
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Resumo
The continuity of the phytochemical study of crude extracts of P. prunifolia’s roots and
branches led to the isolation of five indole-b-carboline alkaloids. Among them, the 10-hydroxyiso-
deppeaninol and N-oxide-10-hydroxy-antirhine derivatives are described here for the first
time. The structures were achieved through 1D and 2D NMR, IR and HRMS analyses. The
branches and roots crude extracts and the alkaloids 14-oxoprunifoleine and strictosamide
showed selective activity against L. amazonensis, with IC50 values of 16.0 and 40.7 mg per mL,
respectively.
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β-carboline alkaloids, Antiprotozoal, Trypanosoma, Leishmania, Psychotria prunifolia, Rubiaceae
Citação
KATO, Lucilia et al. Antiprotozoal alkaloids from Psychotria prunifolia (Kunth) steyerm. Journal of the Brazilian Chemical Society, Campinas, v. 23, n. 2, p. 355-260, 2012.