Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/15289
Tipo do documento: Artigo
Título: Immunological imbalance between IFN-γ and IL-10 levels in the sera of patients with the cardiac form of Chagas disease
Autor: D'Ávila, Daniella Alchaar
Guedes, Paulo Marcos da Matta
Castro, Ana Maria de
Gontijo, Eliane Dias
Chiari, Egler
Galvão, Lúcia Maria da Cunha
Abstract: The immune response is crucial for protection against disease; however, immunological imbalances can lead to heart and digestive tract lesions in chagasic patients. Several studies have evaluated the cellular and humoral im- mune responses in chagasic patients in an attempt to correlate immunological findings with clinical forms of Chagas disease. Moreover, immunoglobulins and cytokines are important for parasitic control and are involved in lesion genesis. Here, cytokine and IgG isotype production were studied, using total epimastigote antigen on sera of chagasic patients with indeterminate (IND, n = 27) and cardiac (CARD, n = 16) forms of the disease. Samples from normal, uninfected individuals (NI, n = 30) were use as controls. The results showed that sera from both IND and CARD patients contained higher levels of Trypanosoma cruzi-specific IgG1 (IgG1) antibodies than sera from NI. No differ- ence in IgG2 production levels was observed between NI, IND and CARD patients, nor was a difference in IL-10 and IFN-γ production detected in the sera of IND, CARD and NI patients. However, IND patients displayed a positive correlation between IL-10 and IFN-γ levels in serum, while CARD patients showed no such correlation, indicating an uncontrolled inflammatory response in CARD patients. These findings support the hypothesis that a lack of efficient regulation between IFN-γ and IL-10 productions in CARD patients may lead to cardiac immunopathology.
Palavras-chave: Trypanosoma cruzi
Chagas disease
Immunopathogenesis
Cytokines
IgG isotype
País: Brasil
Unidade acadêmica: Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
Citação: D'ÁVILA, Daniela A.; GUEDES, Paulo M. M.; CASTRO, Ana M.; GONTIJO, Eliane D.; CHIARI, Egler; GALVÃO, Lúcia M. C. Immunological imbalance between IFN-³ and IL-10 levels in the sera of patients with the cardiac form of Chagas disease. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 104, n. 1, p. 100-105, Feb. 2009.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1590/S0074-02762009000100015
Identificador do documento: 10.1590/S0074-02762009000100015
URI: http://repositorio.bc.ufg.br/handle/ri/15289
Data de publicação: Fev-2009
Aparece nas coleções:IPTSP - Artigos publicados em periódicos

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