Anatomopathological study in Balb/C mice brains experimentally infected with Toxoplasma gondii
Carregando...
Data
2008
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
Toxoplasmosis is one of the most important diseases of the nervous central system, leading to severe symptoms and,
many times, irreversible sequelae. This work demonstrated the main anatomopathological lesions caused by
Toxoplasma gondii in brains from experimentally infected BALB/c mice. We analyzed 51 cases of mice that developed
toxoplasmosis after experimental infection by intraperitoneal inoculation of blood, amniotic liquid and cerebrospinal
fluid from fetuses, newly born children and pregnant women with clinical and laboratory signals of toxoplasmosis.
In all experiments where we detected the parasite in mice we also detected pathological lesions in the animal brains
with great polymorphism between experiments. Edema was the most found lesion in all cases. Besides, it was
possible to demonstrate the inflammatory process in 82.4% of cases and necrosis in 64.7% of cases, in agreement
with the literature that describes severe neurological damage in its hosts.
Descrição
Palavras-chave
Toxoplasmosis, Mice brains, Experimental histopathology
Citação
SILVA, Marcos Gontijo da; LINO JUNIOR, Ruy de Souza; COSTA, Tatiane Luiza da; SOARES, Joanna D'arc Herzog; AMARAL, Waldemar Naves do; AVELINO, Mariza Martins; CASTRO, Ana Maria de. Anatomopathological study in Balb/C mice brains experimentally infected with Toxoplasma gondii. Brazilian Journal of Infectious Diseases, Salvador, v. 12, n. 1, p. 52-56, Feb. 2008.