Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/15337
Tipo do documento: Artigo
Título: Clinical and microbiological features of cryptococcal meningitis
Autor: Souza, Lúcia Kioko Hasimoto e
Costa, Carolina Rodrigues
Fernandes, Orionalda de Fátima Lisboa
Abrão, Fernando Yano
Silva, Thaisa Cristina
Treméa, Carolina Martins
Silva, Maria do Rosário Rodrigues
Abstract: In this study, the clinical features, underlying diseases and clinical outcomes of patients with cryptococcosis were investigated. In addition, a molecular analysis of the Cryptococcus neoformans species complex isolated from these patients was performed. Methods: A prospective study of 62 cases of patients with cryptococcal infection was conducted at the Hospital de Doenças Tropicais de Goiás Dr. Anuar Auad from 2009-2010. Cryptococcal meningitis cases were diagnosed by direct examination and cerebrospinal fl uid (CSF) sample culture. The profi ling of these patients was assessed. The CSF samples were submitted to India ink preparation and cultured on Sabouraud dextrose agar, and C. neoformans was identifi ed by the production of urease, a positive phenoloxidase test and assimilation of carbohydrates. C. neoformans and C. gattii isolates were distinguished by growth on L-canavanine-glycine-bromothymol blue medium, and molecular analysis was conducted via PCR fi ngerprinting reactions using M13 and (GACA) 4 primers. Results: From the 62 patients with cryptococcosis, 71 isolates of CSF were obtained; 67 (94.4%) isolates were identifi ed as C. neoformans var. grubii/VNI, and 4 (5.6%) were identifi ed as C. gattii/VGII. Of these patients, 53 had an HIV diagnosis. The incidence of cryptococcosis was higher among patients 20-40 years of age, with 74.2% of the cases reported in males. Cryptococcus-related mortality was noted in 48.4% of the patients, and the symptoms were altered sensorium, headache, fever and stiff neck. Conclusions: The high morbidity and mortality observed among patients with cryptococcosis demonstrate the importance of obtaining information regarding the epidemiological profi le and clinical course of the disease in the State of Goiás, Brazil.
Palavras-chave: Cryptococcosis
HIV
Epidemiological and clinical features.
País: Brasil
Unidade acadêmica: Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
Citação: SOUZA, Lúcia Kioko Hasimoto e; COSTA, Carolina Rodrigues; FERNANDES, Orionalda de Fátima Lisboa; ABRÃO, Fernando Yano; SILVA, Thaisa Cristina; TREMÉA, Carolina Martins; SILVA, Maria do Rosário Rodrigues. Clinical and microbiological features of cryptococcal meningitis. Revista da Sociedade Brasileira de Medicina Tropical, Uberaba, v. 46, n. 3, p. 343-347, May/June 2013.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1590/0037-8682-0061-2012
Identificador do documento: 10.1590/0037-8682-0061-2012
URI: http://repositorio.bc.ufg.br/handle/ri/15337
Data de publicação: Jun-2013
Aparece nas coleções:IPTSP - Artigos publicados em periódicos

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