Transcriptome overview of Paracoccidioides brasiliensis proteases
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Data
2005
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Resumo
Proteases perform a wide variety of functions inside
and outside cells, regulating many biological processes. Infectious mi-
croorganisms use proteases, either secreted or attached to their cell sur-
face to weaken and invade their hosts. Therefore, proteases are targets
for drugs against a diverse set of diseases. Paracoccidioides brasili-
ensis is the most prevalent fungal pathogen causing systemic mycosis in
Latin America. The development of paracoccidioidomycosis depends
on interactions between fungal and host components and proteases have
been described as important factors implicated in the mechanism of host
colonization by fungi. The primary goal for this study is to present an
overview of the transcriptome sequences - identified cDNAs that en-
code proteases. We obtained a total of 53 cDNAs encoding proteases;
15 were classified as ATP-independent, 12 as ATP-dependent, 22 as
proteasome subunits, and 4 as deubiquitinating proteases. The mechan-
isms and biological activity of these proteases differ in substrate speci-
ficity and in catalytic mechanisms.
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Palavras-chave
Paracoccidioides brasiliensis, Proteasome, Host-fungus interaction, Proteases
Citação
PARENTE, Juliana Alves; COSTA, Milce; PEREIRA, Maristela; SOARES, Célia Maria de Almeida. Transcriptome overview of Paracoccidioides brasiliensis proteases. Genetics and Molecular Research, Ribeirão Preto, v. 4, n. 2, p. 358-371, 2005.