Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/15359
Tipo do documento: Artigo
Título: The cell wall of Paracoccidioides brasiliensis: insights from its transcriptome
Autor: Tomazett, Patrícia Kott
Cruz, Aline Helena da Silva
Bonfim, Sheyla Maria Rondon Caixeta
Soares, Célia Maria de Almeida
Pereira, Maristela
Abstract: The cell wall of a human pathogenic fungus is in contact with the host, serves as a barrier against host defense mechanisms and harbors most fungal antigens. In addition, cell wall biosynthesis path- ways have been recognized as essential to viability and as specific drug targets. Paracoccidioides brasiliensis is a dimorphic fungus that pre- sents mycelium morphology in the free environment and causes infec- tion in a yeast form. The morphogenetic conversion is correlated with changes in the cell wall composition, organization and structure. Based on transcriptome analysis, the enzymes involved in the biosynthesis and remodeling of cell wall polysaccharides, as well as several cell wall- associated molecules of P. brasiliensis, were identified and addressed in further detail.
Palavras-chave: Paracoccidioides brasiliensis
Cell wall-associated enzymes
Cell wall
Dimorphism
País: Brasil
Unidade acadêmica: Instituto de Ciências Biológicas - ICB (RG)
Citação: TOMAZETT, Patrícia Kott; CRUZ, Aline Helena Silva; BONFIM, Sheyla Maria Rondon Caixeta; SOARES, Célia Maria de Almeida; PEREIRA, Maristela. The cell wall of Paracoccidioides brasiliensis: insights from its transcriptome. Genetics and Molecular Research, Ribeirão Preto, v. 4, n. 2, p. 309-325, 2005.
Tipo de acesso: Acesso Aberto
URI: http://repositorio.bc.ufg.br/handle/ri/15359
Data de publicação: 2005
Aparece nas coleções:IPTSP - Artigos publicados em periódicos

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