The cell wall of Paracoccidioides brasiliensis: insights from its transcriptome
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Data
2005
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Resumo
The cell wall of a human pathogenic fungus is in contact
with the host, serves as a barrier against host defense mechanisms and
harbors most fungal antigens. In addition, cell wall biosynthesis path-
ways have been recognized as essential to viability and as specific drug
targets. Paracoccidioides brasiliensis is a dimorphic fungus that pre-
sents mycelium morphology in the free environment and causes infec-
tion in a yeast form. The morphogenetic conversion is correlated with
changes in the cell wall composition, organization and structure. Based
on transcriptome analysis, the enzymes involved in the biosynthesis and
remodeling of cell wall polysaccharides, as well as several cell wall-
associated molecules of P. brasiliensis, were identified and addressed
in further detail.
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Paracoccidioides brasiliensis, Cell wall-associated enzymes, Cell wall, Dimorphism
Citação
TOMAZETT, Patrícia Kott; CRUZ, Aline Helena Silva; BONFIM, Sheyla Maria Rondon Caixeta; SOARES, Célia Maria de Almeida; PEREIRA, Maristela. The cell wall of Paracoccidioides brasiliensis: insights from its transcriptome. Genetics and Molecular Research, Ribeirão Preto, v. 4, n. 2, p. 309-325, 2005.