Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/15379
Tipo do documento: Artigo
Título: The Genome of Anopheles darlingi, the main neotropical malaria vector
Autor: Marinotti, Osvaldo
Cerqueira, Gustavo Coutinho
Almeida, Luiz Gonzaga Paula de
Ferro, Maria Ines Tiraboschi
Loreto, Elgion Lucio da Silva
Zaha, Arnaldo
Teixeira, Santuza Maria Ribeiro
Wespiser, Adam R.
Silva, Alexandre Almeida e
Schlindwein, Aline Daiane
Pacheco, Ana Carolina Landim
Silva, Artur Luiz da Costa da
Graveley, Brenton R.
Walenz, Brian P.
Lima, Bruna de Araujo
Ribeiro, Carlos Alexandre Gomes
Silva, Carlos Gustavo Nunes da
Carvalho, Carlos Roberto de
Soares, Célia Maria de Almeida
Menezes, Claudia Beatriz Afonso de
Matiolli, Cleverson Carlos
Caffrey, Daniel
Araújo, Demetrius Antonio Machado de
Oliveira, Diana Magalhães de
Golenbock, Douglas Taylor
Grisard, Edmundo Carlos
Fantinatti-Garboggini, Fabiana
Carvalho, Fabíola Marques de
Barcellos, Fernando Gomes
Prosdocimi, Francisco
May, Gemma
Azevedo Júnior, Gilson Martins de
Marques, Giselle Moura Guimarães
Goldman, Gustavo Henrique
Padilha, Itácio Queiroz de Mello
Batista, Jacqueline da Silva
Ferro, Jesus Aparecido
Ribeiro, José M. C.
Fietto, Juliana Lopes Rangel
Dabbas, Karina Maia
Cerdeira, Louise Teixeira
Lima, Lucymara Fassarella Agnez
Brocchi, Marcelo
Carvalho, Marcos Oliveira de
Teixeira, Marcus de Melo
Maia, Maria de Mascena Diniz
Goldman, Maria Helena de Souza
Schneider, Maria Paula Cruz
Felipe, Maria Sueli Soares
Cunha, Mariangela Hungria da
Nicolás, Marisa Fabiana
Pereira, Maristela
Montes, Martin Alejandro
Cantão, Mauricio Egídio
Vincentz, Michel Georges Albert
Rafael, Miriam Silva
Silverman, Neal
Stoco, Patrícia Hermes
Souza, Rangel Celso
Santos, Renato Vicentini dos
Gazzinelli, Ricardo Tostes
Neves, Rogério de Oliveira
Silva, Rosane
Astolfi Filho, Spartaco
Maciel, Talles Eduardo Ferreira
Urmenyi, Turan Peter
Tadei, Wanderli Pedro
Camargo, Erney Felicio Plessmann de
Vasconcelos, Ana Tereza Ribeiro de
Abstract: Anopheles darlingi is the principal neotropical malaria vector, responsible for more than a million cases of malaria per year on the American contin- ent. Anopheles darlingi diverged from the African and Asian malaria vectors 100 million years ago (mya) and successfully adapted to the New World environment. Here we present an annotated refer- ence A. darlingi genome, sequenced from a wild population of males and females collected in the Brazilian Amazon. A total of 10 481 predicted protein-coding genes were annotated, 72% of which have their closest counterpart in Anopheles gambiae and 21% have highest similarity with other mosquito species. In spite of a long period of diver- gent evolution, conserved gene synteny was observed between A. darlingi and A. gambiae. More than 10 million single nucleotide polymorph- isms and short indels with potential use as genetic markers were identified. Transposable elements correspond to 2.3% of the A. darlingi genome. Genes associated with hematophagy, immunity and insecticide resistance, directly involved in vector–human and vector–parasite interactions, were identified and discussed. This study repre- sents the first effort to sequence the genome of a neotropical malaria vector, and opens a new window through which we can contemplate the evo- lutionary history of anopheline mosquitoes. It also provides valuable information that may lead to novel strategies to reduce malaria transmission on the South American continent. The A. darlingi genome is accessible at www.labinfo.lncc.br/index. php/anopheles-darlingi.
País: Gra-bretanha
Unidade acadêmica: Instituto de Ciências Biológicas - ICB (RG)
Citação: MARINOTTI, Osvaldo et al. The Genome of Anopheles darlingi, the main neotropical malaria vector. Nucleic Acids Research, Oxford, v. 41, n. 15, p. 7387–7400, Jun. 2013.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1093/nar/gkt484
Identificador do documento: 10.1093/nar/gkt484
URI: http://repositorio.bc.ufg.br/handle/ri/15379
Data de publicação: Jun-2013
Aparece nas coleções:IPTSP - Artigos publicados em periódicos

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