Design, synthesis, antinociceptive and anti-inflammatory activities of novel piroxicam analogues
Carregando...
Data
2012
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
In this paper we report the design, synthesis, antinociceptive and anti-inflammatory
activities of a series of benzothiazine N-acylhydrazones 14a–h, planned by structural
modification of piroxicam (1), a non steroidal anti-inflammatory drug. Among the
synthesized analogues, compounds 14f (LASSBio-1637) and 14g (LASSBio-1639) were
identified as novel antinociceptive and anti-inflammatory prototypes, active by oral
administration, acting by a mechanism of action that seems to be different from that of
piroxicam, since they were inactive as an inhibitor of cyclooxygenase (COX-1 and COX-2)
at concentrations of 10 M.
Descrição
Palavras-chave
Piroxicam, Inflammation, Pain, Acylhydrazone, NSAID, COX
Citação
MIRANDA, Amanda Silva de; BISPO JÚNIOR, Walfrido; SILVA, Yolanda Carla Cupertino da; ALEXANDRE-MOREIRA, Magna Suzana; CASTRO, Rosane de Paula; SABINO, José Ricardo; LIÃO, Luciano Morais; LIMA, Lídia Moreira; BARREIRO, Eliezer J. Design, synthesis, antinociceptive and anti-inflammatory activities of novel piroxicam analogues. Molecules, Basel, v. 17, p. 14126-14145, 2012.