Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/15402
Tipo do documento: Artigo
Título: Transcriptional profiles of the human pathogenic fungus paracoccidioides brasiliensis in mycelium and yeast cells
Autor: Felipe, Maria Sueli Soares
Andrade, Rosângela Vieira de
Arraes, Fabrício Barbosa Monteiro
Nicola, Andre Moraes
Maranhão, Andréa Queiroz
Torres, Fernando Araripe Gonçalves
Pereira, Ildinete Silva
Fonseca, Márcio José Poças
Campos, Élida Geralda
Moraes, Lidia Maria Pepe de
Nicola, Patrícia Albuquerque de Andrade
Tavares, Aldo Henrique Fonseca Pacheco
Silva, Simoneide Sousa
Kyaw, Cynthia Maria
Souza, Diorge Paulo de
Pereira, Maristela
Jesuíno, Rosália Santos Amorim
Andrade, Edmar Vaz de
Rocha, Juliana Alves Parente
Oliveira, Gisele Silva de
Barbosa, Mônica Santiago
Martins, Natalia Florencio
Saltoratto, Ana Lucia Fachin
Cardoso, Renato S.
Passos Júnior, Geraldo Aleixo da Silva
Almeida Junior, Nalvo Franco de
Walter, Maria Emília Machado Telles
Soares, Célia Maria de Almeida
Carvalho, Maria José A.
Brigido, Marcelo de Macedo
Abstract: Paracoccidioides brasiliensis is the causative agent of paracoccidioidomycosis, a disease that affects 10 million individuals in Latin America. This report depicts the results of the analysis of 6,022 assembled groups from mycelium and yeast phase expressed sequence tags, cov- ering about 80% of the estimated genome of this dimor- phic, thermo-regulated fungus. The data provide a com- prehensive view of the fungal metabolism, including overexpressed transcripts, stage-specific genes, and also those that are up- or down-regulated as assessed by in silico electronic subtraction and cDNA microarrays. Also, a significant differential expression pattern in my- celium and yeast cells was detected, which was con- firmed by Northern blot analysis, providing insights into differential metabolic adaptations. The overall transcriptome analysis provided information about se- quences related to the cell cycle, stress response, drug resistance, and signal transduction pathways of the pathogen. Novel P. brasiliensis genes have been identi- fied, probably corresponding to proteins that should be addressed as virulence factor candidates and potential new drug targets.
País: Estados unidos
Unidade acadêmica: Instituto de Ciências Biológicas - ICB (RG)
Citação: FELIPE , Maria Sueli S. et al. Transcriptional profiles of the human pathogenic fungus paracoccidioides brasiliensis in mycelium and yeast cells. Journal of Biological Chemistry, Rockville, v. 280, n. 26, p. 24707-24714, July 2005.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1074/jbc.M500625200
Identificador do documento: 10.1074/jbc.M500625200
URI: http://repositorio.bc.ufg.br/handle/ri/15402
Data de publicação: Jul-2005
Aparece nas coleções:IPTSP - Artigos publicados em periódicos

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