Limitações da vacina BCG e novas estratégias profiláticas contra tuberculose humana
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Data
2009
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Resumo
BCG (Bacille Calmette Guérin), an attenuated vaccine derived from Mycobacterium bovis, is the current vaccine against tuberculosis. Notwithstanding its protection of children, BCG has failed to protect adults against active pulmonary tuberculosis, especially in countries where the disease is endemic. Any new tuberculosis vaccine should protect several categories of people, including children, adults, the elderly and immunodeppressed patients. An important feature is immunization safety for all of these classes. The aim of this review is to describe new vaccination strategies, such as subunit vaccines, DNA vaccines, vaccines with live microorganisms and vectors, and to discuss the application of these new strategies for the control and eradication of tuberculosis.
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Proteínas recombinantes, Tuberculose, BCG, Vacinas de DNA, Vacinas de subunidades, Vacinas contra a tuberculose, Tuberculosis vaccines, Tuberculosis, BCG, Vaccines, Recombinant proteins
Citação
VASCONCELOS JÚNIOR, Arioldo Carvalho et. al. Limitações da vacina BCG e novas estratégias profiláticas contra tuberculose humana. Einstein, São Paulo, v. 7, n. 3, p. 383-389, 2009.