Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/15434
Tipo do documento: Artigo
Título: Identification and biological characterization of Leishmania (Viannia) guyanensis isolated from a patient with tegumentary leishmaniasis in Goiás, a nonendemic area for this species in Brazil
Autor: Pires, Alause da Silva
Borges, Arissa Felipe
Coelho, Adriano Cappellazzo
Dorta, Miriam Cristina Leandro
Lino Junior, Ruy de Souza
Pereira, Ledice Inacia de Araújo
Pinto, Sebastião Alves
Oliveira, Milton Adriano Pelli de
Matos, Grazzielle Guimarães de
Abrahamsohn, Ises de Almeida
Uliana, Silvia Reni Bortolin
Lima, Glória Maria Collet de Araújo
Dias, Fátima Ribeiro
Abstract: The aim of this study was to characterize clinical field isolates of Leishmania spp. obtained from patients with American Tegumentary Leishmaniasis (ATL) who live in Goiás state, Brazil. The presumed areas of infection were in Goiás, Tocantins, and Pará states. Three isolates of parasites were identified as L. (Viannia) braziliensis and one as L. (V.) guyanensis. The in vitro growth profiles were found to be similar for all parasites. Nevertheless, in C57BL/6 mice, L. (V.) guyanensis infection was better controlled than L. (V.) braziliensis. Yet in C57BL/6 mice deficient in interferon gamma, L. (V.) guyanensis lesions developed faster than those caused by L. (V.) braziliensis isolates. In BALB/c mice, the development of lesions was similar for isolates from both species; however, on the 11th week of infection, amastigotes could not be observed in macrophages from L. (V.) guyanensis-infected mice. Thus, L. (V.) guyanensis can be circulating in Goiás, a state where autochthonous cases of this species had not yet been reported. Considering the difficulties to differentiate L. (V.) guyanensis from L. (V.) braziliensis at the molecular, morphological, and clinical (human and murine models) levels, the presence of L. (V.) guyanensis infections is possibly underestimated in several regions of Brazil.
País: Gra-bretanha
Unidade acadêmica: Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
Citação: PIRES, Alause da Silva; BORGES, Arissa Felipe;COELHO, Adriano Cappellazzo; DORTA, Miriam Leandro; LINO JÚNIOR, Ruy de Sousa; PEREIRA, Ledice Inácia de Araújo; PINTO, Sebastião Alves; OLIVEIRA, Milton Adriano Pelli de; MATOS, Grazzielle Guimarães de; ABRAHAMSOHN, Ises A.; ULIANA, Silvia Reni B.; LIMA, Glória Maria Collet de Araújo; RIBEIRO-DIAS, Fátima. Identification and Biological Characterization of Leishmania (Viannia) guyanensis Isolated from a Patient with Tegumentary Leishmaniasis in Goiás, a Nonendemic Area for This Species in Brazil. BioMed Research International, London, v. 2015, p. 1-11, 2015.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1155/2015/350764
Identificador do documento: 10.1155/2015/350764
URI: http://repositorio.bc.ufg.br/handle/ri/15434
Data de publicação: 2015
Aparece nas coleções:IPTSP - Artigos publicados em periódicos

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