Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/15508
Tipo do documento: Artigo
Título: Antifungal activity from Ocimum gratissimum L. towards Cryptococcus neoformans
Autor: Mundim, Janine de Aquino Lemos
Passos, Xisto Sena
Fernandes, Orionalda de Fátima Lisboa
Paula, José Realino de
Ferri, Pedro Henrique
Souza, Lúcia Kioko Hasimoto e
Lemos, Aline de Aquino
Silva, Maria do Rosário Rodrigues
Abstract: Cryptococcal infection had an increased incidence in last years due to the explosion of acquired immune deficiency syndrome epidemic and by using new and effective immunosuppressive agents. The currently antifungal therapies used such as amphotericin B, fluconazole, and itraconazole have certain limitations due to side effects and emergence of resistant strains. So, a permanent search to find new drugs for cryptococcosis treatment is essen- tial. Ocimum gratissimum, plant known as alfavaca (Labiatae family), has been reported earlier with in vitro activity against some bacteria and dermatophytes. In our work, we study the in vitro activity of the ethanolic crude extract, ethyl acetate, hexane, and chloroformic fractions, essential oil, and eugenol of O. gratissimum using an agar dilution susceptibility method towards 25 isolates of Cryptococcus neoformans. All the extracts of O. gratissimum studied showed activity in vitro towards C. neoformans. Based on the minimal inhibitory concentration values the most significant results were obtained with chloroformic fraction and eugenol. It was observed that chloroformic fraction inhibited 23 isolates (92%) of C. neoformans at a concentration of 62.5 μg/ml and eugenol inhibited 4 isolates (16%) at a concentration of 0.9 μg/ml. This screening may be the basis for the study of O. gratissimum as a possible antifungal agent.
Palavras-chave: Ocimum gratissimum
Cryptococcus neoformans
Essential oil
Eugenol
País: Brasil
Unidade acadêmica: Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
Citação: LEMOS, Janine de Aquino; PASSOS, Xisto Sena; FERNANDES, Orionalda de Fátima Lisboa; PAULA, José Realino de; FERRI, Pedro Henrique; SOUZA, Lúcia Kioko Hasimoto e; LEMOS, Aline de Aquino; SILVA, Maria do Rosário Rodrigues. Antifungal activity from Ocimum gratissimum L. towards Cryptococcus neoformans. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, n. 1, p. 55-58, Feb. 2005.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1590/S0074-02762005000100011
Identificador do documento: 10.1590/S0074-02762005000100011
URI: http://repositorio.bc.ufg.br/handle/ri/15508
Data de publicação: Fev-2005
Aparece nas coleções:IPTSP - Artigos publicados em periódicos

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