Occult hepatitis B virus infection among injecting drug users in the central-west region of Brazil
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Data
2013-05
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Resumo
The prevalence of occult hepatitis B virus (HBV) infection was investigated in 149 hepatitis B surface antigen (HB-
sAg) negative injecting drug users (IDUs) in the Central-West Region of Brazil. Of these individuals, 19 were positive
for HBV DNA, resulting in an occult HBV infection prevalence of 12.7% (19/149); six of these 19 individuals had anti-
HBV core and/or anti-HBV surface antibodies and 13 were negative for HBV markers. All IDUs with occult hepatitis
B reported sexual and/or parenteral risk behaviours. All HBV DNA-positive samples were successfully genotyped.
Genotype D was the most common (17/19), followed by genotype A (2/19). These findings reveal a high prevalence of
occult HBV infection and the predominance of genotype D among IDUs in Brazil’s Central-West Region.
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Hepatitis B virus, Genotypes, Occult infection
Citação
MATOS, Marcia Alves Dias de; FERREIRA, Renata Carneiro; RODRIGUES, Fabiana Perez; MARINHO, Tamiris Augusto; LOPES, Carmen Luci Rodrigues; NOVAIS, Antonia Carlos Magalhães; MOTTA-CASTRO, Ana Rita Coimbra; TELES, Sheila Araujo; SOUTO, Francisco Jose Dutra; MARTINS, Regina Maria Bringel. Occult hepatitis B virus infection among injecting drug users in the central-west region of Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 108, n. 3, p. 386-389, May 2013.