Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/15520
Tipo do documento: Artigo
Título: Assessment of BCL2/J(H) translocation in healthy individuals exposed to low-level radiation of 137CsCl in Goiânia, Goiás, Brazil
Autor: Nunes, Hugo Freire
Laranjeira, Angelo Brunelli Albertoni
Yunes, José Andrés
Costa, Emília Oliveira Alves
Melo, Caroline Oliveira de Araújo
Silva, Daniela de Melo e
Cruz, Aparecido Divino da Cruz
Abstract: Healthy radio-exposed individuals who received low levels of Cesium-137 radiation during the accident that occurred in Goiânia in 1987, their families and controls were tested for the detection of t(14;18)-rearranged B cells in peripheral blood by using a highly sensitive, real-time quantitative PCR method. The chromosomal translocation t(14;18)(q32;q21) is characteristic of follicular lymphoma and is a frequent abnormality observed in other types of non-Hodgkin’s lymphoma. This translocation leads to constitutive activation of the BCL2 oncogene by the enhancers of the immunoglobulin heavy-chain locus. In healthy individuals, the same translocation may also be found in a small fraction of peripheral blood lymphocytes, and positive cells might serve as an indicator for environmental exposure to carcinogens and possibly correlate with the cumulative risk of developing t(14;18)- positive non-Hodgkin’s lymphoma. Twenty healthy radio-exposed individuals, 10 relatives and 10 non-exposed healthy individuals were tested for the detection of this translocation. Only 1 non-exposed individual was positive for the chromosomal translocation, and healthy radio-exposed individuals presented lower levels of cells bearing the BCL2/J(H) rearrangement when compared to the levels of the patients with follicular lymphoma before treatment. However, evaluation of more cells would be required to confirm the total absence of circulating cells bearing BCL2/J(H) rearrangement.
Palavras-chave: Cesium-137
Translocation
Lymphoma
Rearrangement
BCL2/J(H)
Radiation
País: Brasil
Unidade acadêmica: Instituto de Ciências Biológicas - ICB (RG)
Citação: NUNES, H. F.; LARANJEIRAS, A. A. B.; YUNES, J. A.; COSTA, E. O. A.; Melo, C. O. A.; SILVA, D. de M. e; CRUZ, A. D. da. Assessment of BCL2/J(H) translocation in healthy individuals exposed to low-level radiation of 137CsCl in Goiânia, Goiás, Brazil. Genetics and Molecular Research, Ribeirão Preto, v. 12, n. 1, p. 28-36, Jan. 2013.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.4238/2013.January.16.6
Identificador do documento: 10.4238/2013.January.16.6
URI: http://repositorio.bc.ufg.br/handle/ri/15520
Data de publicação: Jan-2013
Aparece nas coleções:ICB - Artigos publicados em periódicos

Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
Artigo - Hugo Freire Nunes - 2013.pdf642,8 kBAdobe PDFThumbnail
Baixar/Abrir


Este item está licenciada sob uma Licença Creative Commons Creative Commons